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1. (WO2005116032) REVERSE-TURN MIMETICS AND METHOD RELATING THERETO
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/116032    International Application No.:    PCT/US2005/012799
Publication Date: 08.12.2005 International Filing Date: 15.04.2005
IPC:
C07D 487/04 (2006.01), A61K 31/5513 (2006.01), A61K 45/06 (2006.01), A61P 35/00 (2006.01)
Applicants: CHOONGWAE PHARMA CORPORATION [KR/KR]; 698 Shindaebang-dong, Dongjak-ku, Seoul 156-757 (KR) (For All Designated States Except US).
MOON, Sung Hwan [KR/KR]; (KR) (For US Only).
CHUNG, Jae Uk [KR/KR]; (KR) (For US Only).
LEE, Sung Chan [KR/KR]; (KR) (For US Only).
EGUCHI, Masakatsu [US/US]; (US) (For US Only).
KAHN, Michael [US/US]; (US) (For US Only).
JEONG, Kwang Won [KR/KR]; (KR) (For US Only).
NGUYEN, Cu [US/US]; (US) (For US Only).
LEE, Soo Jin [KR/KR]; (KR) (For US Only)
Inventors: MOON, Sung Hwan; (KR).
CHUNG, Jae Uk; (KR).
LEE, Sung Chan; (KR).
EGUCHI, Masakatsu; (US).
KAHN, Michael; (US).
JEONG, Kwang Won; (KR).
NGUYEN, Cu; (US).
LEE, Soo Jin; (KR)
Agent: LIN, Qing; Seed Intellectual Property Law Group PLLC, Suite 6300, 701 Fifth Avenue, Seattle, Washington 98104-7092 (US)
Priority Data:
10/826,972 16.04.2004 US
Title (EN) REVERSE-TURN MIMETICS AND METHOD RELATING THERETO
(FR) MIMETIQUES DE COUDES INVERSES ET PROCEDE ASSOCIE
Abstract: front page image
(EN)Conformationally constrained compounds that mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the reverse-turn mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members. The invention also relates to the use of such compounds for inhibiting or treating disorders modulated by Wnt-signaling pathway, such as cancer, especially colorectal cancer, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, rheumatoid arthritis disease, tuberous sclerosis complex, Alzheimer's disease, excess hair growth or loss, or ulcerative colitis.
(FR)L'invention concerne des composés conformationnellement contraints qui imitent la structure secondaire de régions à coudes inverses de peptides et de protéines biologiquement actifs. De telles structures mimétiques de coudes inverses ont une utilité dans un grand nombre de domaines, notamment en tant qu'agents diagnostiques et thérapeutiques. L'invention concerne également des bibliothèques contenant les structures mimétiques de coudes inverses de la présente invention, ainsi que des procédés de criblage de celles-ci, en vue d'identifier des éléments biologiquement actifs. L'invention concerne en outre l'utilisation de ces composés pour l'inhibition ou le traitement de troubles modulés par une voie de signalisation, tels que le cancer, en particulier le cancer colorectal, la resténose consécutive à l'angioplastie, la maladie polykystique des reins, l'angiogenèse aberrante, l'arthrite rhumatoïde, le syndrome de la sclérose tubéreuse, la maladie d'Alzheimer, la croissance ou la perte excessive de cheveux, ou la colite ulcéreuse.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)