WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2005115981) A PROCESS FOR THE PREPARATION OF 1-(9H-CARBAZOL-4-YLOXY)-3-2-(-METHOXYPHENOXY)-ETHYL AMINO-PROPAN-2-OL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/115981    International Application No.:    PCT/IN2005/000139
Publication Date: 08.12.2005 International Filing Date: 03.05.2005
IPC:
C07D 209/88 (2006.01), C07D 405/12 (2006.01)
Applicants: USV LIMITED [IN/IN]; BSD Marg, Govandi, Mumbai 400 088, Maharashtra (IN) (For All Designated States Except US).
TARUR, Venkatasubramanian, Radhakrishnan [IN/IN]; (IN) (For US Only).
SATHE, Dhananjay, Govind [IN/IN]; (IN) (For US Only).
KULKARNI, Swapnil, Jayant [IN/IN]; (IN) (For US Only)
Inventors: TARUR, Venkatasubramanian, Radhakrishnan; (IN).
SATHE, Dhananjay, Govind; (IN).
KULKARNI, Swapnil, Jayant; (IN)
Agent: NAIR, Gopakumar, G.; Patent & Trademark Agent (Regd.), Gopakumar Nair Associates, Nair Baug, Akuli Road, Kandivli (East), Mumbai 400 101 Maharashtra (IN)
Priority Data:
479/MUM/2004 07.05.2004 IN
Title (EN) A PROCESS FOR THE PREPARATION OF 1-(9H-CARBAZOL-4-YLOXY)-3-2-(-METHOXYPHENOXY)-ETHYL AMINO-PROPAN-2-OL
(FR) NOUVEAU PROCEDE DE PREPARATION DE 1-(9H-CARBAZOL-4-YLOXY)-3-[[2-(-METHOXYPHENOXY)-ETHYL] AMINO]-PROPAN-2-OL
Abstract: front page image
(EN)The present invention discloses a novel process for preparation of carvedilol by using eco friendly solvents to obtain the said carvedilol in high purity. The said process comprises, reacting 4-hydroxy carbazole of formula (IV) with epichlorhydrin in presence of an organic solvent and a base at temperatures between 10°C - 30°C; further reacting the resultant 4-(2,3-epoxypropoxy)- carbazole of formula (II) with a salt of 2-(2­methoxyphenoxy) ethylamine of formula (III), preferably hydrochloride salt in presence of a base and a hydroxylic solvent at temperatures between 30°C - 90°C.
(FR)La présente invention concerne un nouveau procédé permettant de préparer du carvedilol au moyen de solvants écologiques afin d'obtenir du carvedilol d'une grande pureté. Le procédé décrit dans cette invention consiste à faire réagir du 4-hydroxy carbazole présentant la formule (IV) avec de l'épichlorhydrine en présence d'un solvant organique et d'une base à des températures comprises entre 10°C et 30°C; puis à faire réagir le 4-(2,3-epoxypropoxy)-carbazole obtenu et représenté par la formule (II) avec un sel de 2-(2-methoxyphenoxy) ethylamine représenté par la formule (III), de préférence, du sel de chlorhydrate en présence d'une base et d'un solvant hydroxylique à des températures comprises entre 30°C et 90°C.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)