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Pub. No.:    WO/2005/115475    International Application No.:    PCT/JP2005/009727
Publication Date: 08.12.2005 International Filing Date: 27.05.2005
A61K 47/36 (2006.01), A61K 9/08 (2006.01), A61K 47/38 (2006.01), A61P 27/02 (2006.01)
Applicants: SANTEN PHARMACEUTICAL CO., LTD. [JP/JP]; 9-19, Shimoshinjo 3-chome, Higashiyodogawa-ku, Osaka-shi, Osaka 5338651 (JP) (For All Designated States Except US).
SAKAMOTO, Kayoko [JP/JP]; (JP) (For US Only).
KIMURA, Akio [JP/JP]; (JP) (For US Only).
HIRAI, Shin-ichiro [JP/JP]; (JP) (For US Only).
NAKAMURA, Masatsugu [JP/JP]; (JP) (For US Only)
Inventors: SAKAMOTO, Kayoko; (JP).
KIMURA, Akio; (JP).
HIRAI, Shin-ichiro; (JP).
NAKAMURA, Masatsugu; (JP)
Agent: HIBI, Norihiko; c/o KISHIMOTO & CO., 3rd Floor Inaba Building, 13-18 Nishishinsaibashi 1-chome, Chuo-ku Osaka-shi, Osaka 5420086 (JP)
Priority Data:
2004-157574 27.05.2004 JP
2004-248586 27.08.2004 JP
(JA) 眼科用粘稠化剤
Abstract: front page image
(EN)It is intended to provide eye-drops which have a relatively low viscosity before the instillation but are thickened on the eyeball surface at the instillation. Eye-drops containing a thickener for ophthalmic use, which comprises a combination of hydroxyethylcellulose with dextran, exhibit a specific and synergistic thickening effect in the coexistence of mucin. Upon contact with mucin in the lacrimal layer at the instillation, therefore, the above eye-drops are thickened on the eyeball surface to thereby sustain the desired drug effect and refreshing feel.
(FR)On cherche à fournir un collyre de relativement faible viscosité avant l’instillation mais qui s’épaissit sur la surface du globe oculaire lors de l’instillation. Le collyre contient un épaississant à usage ophtalmique, composé d'une combinaison d’ hydroxyéthylcellulose et de dextran, a un effet épaississant synergétique et spécifique au contact de la mucine. Lors de l’instillation, le contact de la mucine dans la couche lacrymale entraîne donc l’épaississement du collyre sur la surface du globe oculaire, ayant ainsi pour résultat l’effet médical souhaité et une sensation rafraîchissante.
(JA) 本発明は点眼前には比較的低粘度でありながら、点眼時に眼球表面で増粘するする点眼液を提供することを課題とする。ヒドロキシエチルセルロースとデキストランとの組み合わせからなる眼科用粘稠化剤を含有する点眼液は、ムチンの共存下で特異的に相乗的な増粘効果を発揮する。したがって、本発明の点眼液は、点眼時に涙液層中のムチンと接触することにより、点眼液が眼球表面で増粘して所望の薬効や清涼感を持続することができる。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)