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Machine translation
1. (WO2005115383) SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/115383    International Application No.:    PCT/US2005/018318
Publication Date: 08.12.2005 International Filing Date: 24.05.2005
IPC:
C07D 249/06 (2006.01), A01N 43/647 (2006.01)
Applicants: METABOLEX, INC. [US/US]; 3876 Bay Center Place, Hayward, California 94545 (US) (For All Designated States Except US).
ZHU, Yan [CN/US]; (US) (For US Only).
MA, Jingyuan [CN/US]; (US) (For US Only).
CHENG, Peng [CN/US]; (US) (For US Only).
ZHAO, Zuchun [US/US]; (US) (For US Only).
GREGOIRE, Francine M. [BE/US]; (US) (For US Only).
RAKHMANOVA, Vera A. [RU/US]; (US) (For US Only)
Inventors: ZHU, Yan; (US).
MA, Jingyuan; (US).
CHENG, Peng; (US).
ZHAO, Zuchun; (US).
GREGOIRE, Francine M.; (US).
RAKHMANOVA, Vera A.; (US)
Agent: HOPKINS, Mark H.; Townsend and Townsend and Crew LLP, Two Embarcadero Center, 8th Floor, San Francisco, California 94111 (US)
Priority Data:
60/574,426 25.05.2004 US
Title (EN) SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
(FR) TRIAZOLES SUBSTITUÉS COMME MODULATEURS DE PPAR ET MÉTHODES DE PRÉPARATION
Abstract: front page image
(EN)The present invention is directed to certain novel triazole compounds represented by Formula: (I); and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
(FR)Cette invention concerne certains nouveaux composés de triazole représentés par des sels, des solvates, des hydrates et des promédicaments de Formule I et acceptables d’un point de vue pharmaceutique. Elle concerne également les méthodes de production et d’emploi de ces composés et des compositions pharmaceutiques les contenant destinées au traitement et au contrôle de maladies déclenchées par des PPAR, telles le métabolisme glucosé, le métabolisme et la sécrétion d’insuline, plus spécialement le diabète du Type 2, l’hyperinsulémie, l’hyperlipidémie, l’hyperuricémie, l’hypercholestérémie, l’athérosclérose, un ou plusieurs facteurs de risque de trouble cardiovasculaire, le Syndrome X, l’hypertriglycéridémie, l’hyperglycémie, l’obésité et les troubles alimentaires.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)