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Machine translation
1. (WO2005115333) A BIOMOLECULE-CONTAINING FORMULATION OF INCREASED STABILITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/115333    International Application No.:    PCT/US2005/017914
Publication Date: 08.12.2005 International Filing Date: 23.05.2005
Chapter 2 Demand Filed:    24.10.2005    
IPC:
A61K 38/21 (2006.01), A61K 9/00 (2006.01), A61K 9/16 (2006.01), A61K 47/18 (2006.01)
Applicants: ALZA CORPORATION [US/US]; Patent Law Department, 1900 Charleston Road, Mountain View, CA 94043 (US) (For All Designated States Except US).
JUNNARKAR, Gunjan [US/US]; (US) (For US Only).
DESJARDIN, Michael A. [US/US]; (US) (For US Only).
LIU, Kui [US/US]; (US) (For US Only).
LI, Zengji [US/US]; (US) (For US Only)
Inventors: JUNNARKAR, Gunjan; (US).
DESJARDIN, Michael A.; (US).
LIU, Kui; (US).
LI, Zengji; (US)
Agent: ADEBIYI, Adenike A.; Dewipat Incorporated, P.O. Box 1017, Cypress, TX 77410-1017 (US)
Priority Data:
60/574,662 25.05.2004 US
60/650,226 03.02.2005 US
Title (EN) A BIOMOLECULE-CONTAINING FORMULATION OF INCREASED STABILITY
(FR) FORMULATIONS STABLES LORS DE LA TRANSITION D'UN EXCIPIENT HYDROPHOBE VERS UN SUPPORT HYDROPHILE
Abstract: front page image
(EN)A suspension formulation for therapeutic use includes a non-aqueous, hydrophobic vehicle exhibiting viscous fluid characteristics, a dry particle formulation comprising a biomolecule dispersed in the vehicle, and a surfactant incorporated in at least one of the vehicle and dry particle formulation. A dry particle formulation includes an interferon, a buffer, a surfactant, and one or more stabilizers selected from the group consisting of a carbohydrate, an antioxidant, and an amino acid.
(FR)L'invention concerne une formulation en suspension à usage thérapeutique qui renferme un excipient hydrophobe non aqueux présentant des caractéristiques fluidiques visqueuses, une formulation particulaire sèche comprenant une biomolécule dispersée dans un excipient, et un tensioactif incorporé dans au moins l'excipient ou la formulation particulaire sèche. Une formulation particulaire sèche comporte un interféron, un tampon, un tensioactif et au moins un stabilisateur choisi dans le groupe constitué d'un glucide, d'un antioxydant, et d'un acide aminé.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)