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1. (WO2005114179) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH NUCLEAR RECEPTOR SUBFAMILY 0, GROUP B, MEMBER 1 (NR0B1)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/114179    International Application No.:    PCT/EP2005/004709
Publication Date: 01.12.2005 International Filing Date: 30.04.2005
IPC:
G01N 33/50 (2006.01), C12Q 1/68 (2006.01), A61K 38/17 (2006.01)
Applicants: BAYER HEALTHCARE AG [DE/DE]; 51368 Leverkusen (DE) (For All Designated States Except US).
GOLZ, Stefan [DE/DE]; (DE) (For US Only).
BRÜGGEMEIER, Ulf [DE/DE]; (DE) (For US Only).
GEERTS, Andreas [DE/DE]; (DE) (For US Only)
Inventors: GOLZ, Stefan; (DE).
BRÜGGEMEIER, Ulf; (DE).
GEERTS, Andreas; (DE)
Common
Representative:
BAYER HEALTHCARE AG; Law and Patents, Patents and Licensing, 51368 Leverkusen (DE)
Priority Data:
04011360.7 13.05.2004 EP
Title (EN) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH NUCLEAR RECEPTOR SUBFAMILY 0, GROUP B, MEMBER 1 (NR0B1)
(FR) DIAGNOSTIC ET THERAPIE DESTINES AUX MALADIES ASSOCIEES A UNE SOUS-FAMILLE 0 DE RECEPTEURS NUCLEAIRES, GROUPE B, ELEMENT 1 (NR0B1)
Abstract: front page image
(EN)The invention provides a human NR0B1 which is associated with the cardiovascular diseases, endocrinological diseases, cancer, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, endocrinological diseases, cancer, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of NR0B1 as well as pharmaceutical compositions comprising such compounds.
(FR)L'invention concerne un NR0B1 humain associé aux maladies cardio-vasculaires, aux maladies endocriniennes, au cancer, aux maladies métaboliques, à l'inflammation, aux maladies gastro-entériennes, aux maladies hématologiques, aux maladies des muscles et du squelette, aux maladies neurologiques ou urologiques. L'invention concerne aussi des dosages destinés à l'identification de composés utiles dans le traitement ou la prévention des maladies cardio-vasculaires, des maladies endocriniennes, du cancer, des maladies métaboliques, de l'inflammation, des maladies gastro-entériennes, des maladies hématologiques, des maladies des muscles et du squelette, des maladies neurologiques ou urologiques. L'invention concerne enfin des composés qui se lient à NR0B1 et/ou activent ou inhibent l'activité de NR0B1 ainsi que des compositions pharmaceutiques comprenant ces composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)