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1. (WO2005113787) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-DEPENDENT RECEPTOR KINASE 1 (GRK1)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/113787    International Application No.:    PCT/EP2005/004898
Publication Date: 01.12.2005 International Filing Date: 06.05.2005
IPC:
G01N 33/574 (2006.01), G01N 33/68 (2006.01)
Applicants: BAYER HEALTHCARE AG [DE/DE]; 51368 Leverkusen (DE) (For All Designated States Except US).
GOLZ, Stefan [DE/DE]; (DE) (For US Only).
BRÜGGEMEIER, Ulf [DE/DE]; (DE) (For US Only).
GEERTS, Andreas [DE/DE]; (DE) (For US Only)
Inventors: GOLZ, Stefan; (DE).
BRÜGGEMEIER, Ulf; (DE).
GEERTS, Andreas; (DE)
Common
Representative:
BAYER HEALTHCARE AG; Law and Patents, Patents and Licensing, 51368 Leverkusen (DE)
Priority Data:
04012023.0 21.05.2004 EP
Title (EN) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-DEPENDENT RECEPTOR KINASE 1 (GRK1)
(FR) METHODES DIAGNOSTIQUES ET THERAPEUTIQUES POUR LUTTER CONTRE DES LES MALADIES ASSOCIEES A LA KINASE 1 SPECIFIQUE DU RECEPTEUR COUPLE A UNE PROTEINE G (GRK1)
Abstract: front page image
(EN)The invention provides a human GRK1 which is associated with cardiovasular diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovasular diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GRK1 as well as pharmaceutical compositions comprising such compounds.
(FR)L'invention concerne une GRK1 humaine associée aux maladies cardiovasculaires, aux maladies endocrinologiques, aux maladies métaboliques, au cancer, aux maladies gastroentérologiques, à l'inflammation, aux maladies hématologiques, aux maladies des muscles squelettiques, aux maladies neurologiques ainsi qu'aux maladies urologiques. Par ailleurs, l'invention concerne des analyses d'identification de composés utilisés dans le traitement ou la prévention des maladies cardiovasculaires, des maladies endocrinologiques, des maladies métaboliques, du cancer, des maladies gastroentérologiques, de l'inflammation, des maladies hématologiques, des maladies des muscles squelettiques, des maladies neurologiques ainsi que des maladies urologiques. L'invention concerne en outre des composés qui se lient à et/ou qui activent ou inhibent l'activité de GRK, ainsi que des compositions pharmaceutiques qui contiennent ces composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)