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1. (WO2005113557) METHOD FOR THE CATALYTIC PRODUCTION OF HYDROCODONE AND HYDROMORPHONE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/113557    International Application No.:    PCT/US2004/035292
Publication Date: 01.12.2005 International Filing Date: 25.10.2004
IPC:
C07D 489/02 (2006.01)
Applicants: MALLINCKRODT, INC.; 675 McDonnell Blvd., St. Louis, MO 63134 (US) (For All Designated States Except US).
WANG, Peter Xianqi [US/US]; (US) (For US Only).
WHITE, Carl Ray [US/US]; (US) (For US Only)
Inventors: WANG, Peter Xianqi; (US).
WHITE, Carl Ray; (US)
Agent: REBMAN, Christine, M.; Mallinckrodt, Inc., 675 McDonnell Boulevard, St. Louis, Missouri 63134 (US)
Priority Data:
PCT/US03/35462 05.11.2003 US
10/495,503 13.05.2004 US
Title (EN) METHOD FOR THE CATALYTIC PRODUCTION OF HYDROCODONE AND HYDROMORPHONE
(FR) PROCÉDÉ POUR LA PRODUCTION CATALYTIQUE D'HYDROCODONE ET D'HYDROMORPHONE
Abstract: front page image
(EN)A method for the catalytic conversion of codeine, morphine or analogs thereof into hydrocodone, hydromorphone or analogs thereof utilizing a transition metal catalyst of the formula [M(PR3R4R5)nXm]p; wherein R1 is H, alkyl, aryl or acyl; M is a Group VIII transition metal; R3, R4 and R5 are selected from the group consisting of alkyl, aryl, alkoxyl, phenoxyl and combinations thereof; X is a halide or an anion; n is 1, 2, 3 or 4; m is 1 or 2; and p is at least 1.
(FR)Un procédé pour conversion catalytique de codéine, morphine ou analogues de celles-ci en hydrocodone, hydromorphone ou analogues de celles-ci en utilisant un catalyseur métallique de transition de formule [M(PR3R4R5)nXm]p; dans laquelle R1 est un H, un alkyle, un aryle ou un acyle; M est un métal de transition du groupe VII; R3, R4 et R5 sont sélectionnés à partir du groupe consistant en alkyle, aryle, alkoxyle, phénoxyle et combinaisons de ceux-ci; X est un halogénure ou un anion; n est 1, 2, 3 ou 4; m est 1 ou 2; et p est au moins égal à 1.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)