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1. (WO2005113551) BICYCLIC-SUBSTITUTED AMINES HAVING CYCLIC-SUBSTITUTED MONOCYCLIC SUBSTITUENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/113551    International Application No.:    PCT/US2005/014863
Publication Date: 01.12.2005 International Filing Date: 29.04.2005
IPC:
C07D 417/14 (2006.01), C07D 401/04 (2006.01), C07D 417/04 (2006.01), C07D 413/04 (2006.01), C07D 409/14 (2006.01), C07D 413/14 (2006.01), C07D 215/12 (2006.01), C07D 401/14 (2006.01), A61K 31/4709 (2006.01), A61P 25/28 (2006.01), A61P 25/00 (2006.01)
Applicants: ABBOTT LABORATORIES [US/US]; Dept. 377 Bldg AP6A-1, 100 Abbott Park Road, Abbott Park, IL 60064-6008 (US) (For All Designated States Except US).
ALTENBACH, Robert, J. [US/US]; (US) (For US Only).
BLACK, Lawrence, A. [US/US]; (US) (For US Only).
CHANG, Sou-jen [US/US]; (US) (For US Only).
COWART, Marlon, D. [US/US]; (US) (For US Only).
FAGHIH, Ramin [US/US]; (US) (For US Only).
GFESSER, Gregory, A. [US/US]; (US) (For US Only).
KU, Yi-yin [US/US]; (US) (For US Only).
LIU, Huaqing [CN/US]; (US) (For US Only).
LUKIN, Kirill, A. [US/US]; (US) (For US Only).
NERSESIAN, Diana, L. [US/US]; (US) (For US Only).
PU, Yu-ming [US/US]; (US) (For US Only).
CURTIS, Michael, P. [US/US]; (US) (For US Only)
Inventors: ALTENBACH, Robert, J.; (US).
BLACK, Lawrence, A.; (US).
CHANG, Sou-jen; (US).
COWART, Marlon, D.; (US).
FAGHIH, Ramin; (US).
GFESSER, Gregory, A.; (US).
KU, Yi-yin; (US).
LIU, Huaqing; (US).
LUKIN, Kirill, A.; (US).
NERSESIAN, Diana, L.; (US).
PU, Yu-ming; (US).
CURTIS, Michael, P.; (US)
Agent: CHEN, Portia; Dept. 377 Bldg AP6A-1, 100 Abbott Park Road, Abbott Park, IL 60064-6008 (US)
Priority Data:
10/843,742 12.05.2004 US
Title (EN) BICYCLIC-SUBSTITUTED AMINES HAVING CYCLIC-SUBSTITUTED MONOCYCLIC SUBSTITUENTS
(FR) AMINES À SUBSTITUTION BICYCLIQUE AYANT DES SUBSTITUANTS MONOCYCLIQUES À SUBSTITUTION CYCLIQUE
Abstract: front page image
(EN)Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X', Y, Y', Z, Z', R1, R2, R3, R3a, R3b, R4, R5, L, L2, and L3 are as defined herein, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
(FR)Des composés de formule (I) où R1 ou R2 est un cycle aromatique ou non aromatique directement lié ou lié par un liant, tel que représenté par L2 et L3, à un noyau hétéroaromatique, et X, X', Y, Y', Z, Z', R1, R2, R3, R3a, R3b, R4, R5, L, L2, et L3 sont tels que définis ici, sont utiles pour le traitement de maladies ou de troubles prévenus ou améliorés par des ligands du récepteur de l’histamine-3. Sont également décrites des compositions pharmaceutiques comprenant des ligands du récepteur de l’histamine-3, des procédés pour l’utilisation de tels composés et compositions, et un procédé pour préparer des composés dans le champ d’application de la formule (I).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)