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Machine translation
1. (WO2005113544) SUBSTANTIALLY PURE 2-{[2-(2-METHYLAMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBONYL]-AMINO}-3-(PHENYLPYRIDIN-2-YL-AMINO)-PROPIONIC ACID AS AN IKB KINASE INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/113544    International Application No.:    PCT/US2005/016381
Publication Date: 01.12.2005 International Filing Date: 11.05.2005
Chapter 2 Demand Filed:    10.02.2006    
IPC:
C07D 401/14 (2006.01), A61K 31/506 (2006.01), A61P 11/06 (2006.01)
Applicants: AVENTIS PHARMACEUTICALS INC. [US/US]; 300 Somerset Corporate Boulevard, Bridgewater, NJ 08807-2854 (US) (For All Designated States Except US).
HADDAD, El-Bdaoui [FR/US]; (US) (For US Only).
RITZELER, Olaf [DE/DE]; (DE) (For US Only).
ALDOUS, David, J. [US/US]; (US) (For US Only).
COX, Paul, Joseph [GB/US]; (US) (For US Only)
Inventors: HADDAD, El-Bdaoui; (US).
RITZELER, Olaf; (DE).
ALDOUS, David, J.; (US).
COX, Paul, Joseph; (US)
Agent: KNIGHT, Julie, Anne; sanofi-aventis, Route 202-206, P. O. Box 6800, Bridgewater, NJ 08807-0800 (US)
Priority Data:
60/570,146 12.05.2004 US
Title (EN) SUBSTANTIALLY PURE 2-{[2-(2-METHYLAMINO-PYRIMIDIN-4-YL)-1H-INDOLE-5-CARBONYL]-AMINO}-3-(PHENYLPYRIDIN-2-YL-AMINO)-PROPIONIC ACID AS AN IKB KINASE INHIBITOR
(FR) 2-{[2-(2-MÉTHYLAMINO-PYRIMIDINE-4-YL)-1H-INDOLE-5-CARBONYLE]-AMINÉ}-3-(PHÉNYLPYRIDINE-2-YL-AMINÉ)-ACIDE PROPIONIQUE SUBSTANTIELLEMENT PUR COMME INHIBITEUR DE KINASE IKB
Abstract: front page image
(EN)The present invention is directed to the substantially pure compound of formula (A), or pharmaceutically acceptable salt, or solvate of said compound; to a pharmaceutical composition comprising a pharmaceutically effective amount of the compound of formula (A), and a pharmaceutically acceptable carrier; and the use of a compound of formula (A) having activity as an inhibitor, preferably a selective inhibitor, of IkB (IKK), particularly IKK-2, and methods related thereto.
(FR)La présente invention est destinée au composé substantiellement pur de formule (A) ou à un sel pharmaceutiquement acceptable ou un solvat dudit composé ; à une composition pharmaceutique comprenant la quantité pharmaceutiquement efficace du composé de formule (A) et un vecteur pharmaceutiquement acceptable ; l'utilisation d'un composé de formule (A) ayant une activité d'inhibiteur, de préférence un inhibiteur sélectif, de IkB (IKK), en particulier IKK-2 et les méthodes liées à cela.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)