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1. (WO2005113542) N-CYCLIC SULFONAMIDO INHIBITORS OF GAMMA SECRETASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/113542    International Application No.:    PCT/US2005/017985
Publication Date: 01.12.2005 International Filing Date: 20.05.2005
IPC:
C07D 401/04 (2006.01), C07D 209/42 (2006.01), C07D 277/06 (2006.01), C07D 491/10 (2006.01), C07D 215/58 (2006.01), C07D 241/50 (2006.01), C07D 263/56 (2006.01), A61K 31/4406 (2006.01), A61P 25/28 (2006.01), C07D 405/06 (2006.01), C07D 235/02 (2006.01), C07D 217/22 (2006.01), C07D 273/00 (2006.01), C07D 243/14 (2006.01), C07D 471/04 (2006.01)
Applicants: ELAN PHARMACEUTICALS, INC. [US/US]; 800 Gateway Boulevard, South San Francisco, CA 94080 (US) (For All Designated States Except US).
NEITZEL, Martin, L. [US/US]; (US) (For US Only).
MARUGG, Jennifer, L. [US/US]; (US) (For US Only)
Inventors: NEITZEL, Martin, L.; (US).
MARUGG, Jennifer, L.; (US)
Agent: CRAWFORD, Bradley, W.; McDonnell Boehnen Hulbert & Berghoff LLP, 300 S. Wacker Drive, Suite 3100, Chicago, IL 60606 (US)
Priority Data:
60/572,862 20.05.2004 US
Title (EN) N-CYCLIC SULFONAMIDO INHIBITORS OF GAMMA SECRETASE
(FR) INHIBITEURS SULFONAMIDO N-CYCLIQUES DE GAMMA-SECRETASE
Abstract: front page image
(EN)The invention provides N-cyclic sulfonamido compounds for use in treating or preventing cognitive disorders, such as Alzheimer’s Disease. Compounds of particular interest are defined by Formula (I), wherein R4, R5, R6, R7 and R8 are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders, including Alzheimer’s disease using compounds of Formula (I).
(FR)L'invention concerne des composés sulfonamido N-cycliques qui s'utilisent dans le traitement ou la prévention des troubles cognitifs, tels que la maladie d'Alzheimer. Des composés revêtant un intérêt particulier sont représentés par la formule (I), dans laquelle R4, R5, R6, R7 et R8 sont tels que décrits dans le descriptif. Par ailleurs, l'invention concerne des compositions pharmaceutiques qui contiennent les composés représentés par la formule (I), ainsi que des méthodes de traitement des troubles cognitifs, y compris la maladie d'Alzheimer, au moyen des composés de la formule (I).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)