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1. (WO2005113525) N, N’-SUBSTITUTED-1,3-DIAMINO-2-OXOPROPANE DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS AND USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/113525    International Application No.:    PCT/EP2005/005586
Publication Date: 01.12.2005 International Filing Date: 19.05.2005
IPC:
C07D 275/02 (2006.01), C07D 279/02 (2006.01), C07D 207/26 (2006.01), A61K 31/4015 (2006.01), A61K 31/425 (2006.01), A61K 31/54 (2006.01), A61P 25/28 (2006.01)
Applicants: GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House, Berkeley Avenue, Greenford Middlesex UB6 0NN (GB) (For All Designated States Except US).
DEMONT, Emmanuel, Hubert [FR/GB]; (GB) (For US Only).
REDSHAW, Sally [GB/GB]; (GB) (For US Only).
WALTER, Daryl, Simon [GB/GB]; (GB) (For US Only)
Inventors: DEMONT, Emmanuel, Hubert; (GB).
REDSHAW, Sally; (GB).
WALTER, Daryl, Simon; (GB)
Agent: GODDARD, Carolyn, Janice; GlaxoSmithKline, Corporate Intellectual Property (CN925.1), 980 Great West Road, Brentford Middlesex TW8 9GS (GB)
Priority Data:
0411404.7 21.05.2004 GB
Title (EN) N, N’-SUBSTITUTED-1,3-DIAMINO-2-OXOPROPANE DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS AND USE
(FR) DERIVES -1,3-DIAMINO-2-OXOPROPANE N, N'-SUBSTITUE ET COMPOSITIONS PHARMACEUTIQUE DE CES COMPOSES ET UTILISATION
Abstract: front page image
(EN)The present invention relates to novel ketone compounds having Asp2 (&bgr;-secretase, BACE1 or Memapsin 2) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated &bgr;- amyloid levels or &bgr;-amyloid deposits, particularly Alzheimer's disease.
(FR)La présente invention concerne ce nouveaux composés cétone possédant une activité inhibitrice Asp2 (?-secrétase, BACE1 ou Memapsine 2), des processus de préparation de ces composés, des compositions contenant ces composés et leur utilisation dans le traitement de maladies caractérisées par des taux d'amyloïdes B élevés ou des dépôts d'amyloïdes ?, la maladie d'Alzheimer, en particulier.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)