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1. (WO2005113522) AZOLE CARBOXAMIDE INHIBITORS OF BACTERIAL TYPE III PROTEIN SECRETION SYSTEMS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/113522    International Application No.:    PCT/US2005/016105
Publication Date: 01.12.2005 International Filing Date: 06.05.2005
Chapter 2 Demand Filed:    07.12.2005    
IPC:
C07D 263/34 (2006.01), C07D 277/56 (2006.01), C07D 233/90 (2006.01), C07D 249/10 (2006.01), C07D 413/04 (2006.01), C07D 413/10 (2006.01), C07D 417/10 (2006.01), C07D 413/14 (2006.01), C07D 231/14 (2006.01), A61K 31/421 (2006.01), A61P 31/04 (2006.01)
Applicants: JANSSEN PHARMACEUTICA, N.V. [BE/BE]; Turnhoutseweg 30, B-2340 Beerse (BE) (For All Designated States Except US).
LI, Xiaobing [US/US]; (US) (For US Only).
MURRAY, William, V. [US/US]; (US) (For US Only).
MACIELAG, Mark, J. [US/US]; (US) (For US Only).
GUAN, Qunying [CN/US]; (US) (For US Only)
Inventors: LI, Xiaobing; (US).
MURRAY, William, V.; (US).
MACIELAG, Mark, J.; (US).
GUAN, Qunying; (US)
Agent: JOHNSON, Philip, S.; Johnson & Johnson, One Johnson & Johnson Plaza, New Brunswick, New Jersey 08933 (US)
Priority Data:
60/568,851 07.05.2004 US
Title (EN) AZOLE CARBOXAMIDE INHIBITORS OF BACTERIAL TYPE III PROTEIN SECRETION SYSTEMS
(FR) INHIBITEURS CARBOXAMIDES D'AZOLE DE SYSTÈMES BACTÉRIENS DE SÉCRÉTION DE PROTÉINE DE TYPE III
Abstract: front page image
(EN)In accordance with the present invention, compounds of formula (I) that inhibit Type III protein secretion have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of Type III protein secretion and/or in the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections, are provided. In another aspect of the invention, methods are provided for the inhibition of Type III protein secretion and/or the treatment and prevention of bacterial infections, particularly Gram-negative bacterial infections using the compounds of the invention. Formula (I):
(FR)L'invention concerne des composés identifiés de formule (I) qui inhibent une sécrétion de protéine de type III, et des procédés d'utilisation de ces composés. Dans un mode de réalisation, l'invention se rapporte à des composés servant à inhiber une sécrétion de protéine de type III et/ou à traiter et prévenir des infections bactériennes, en particulier des infections bactériennes à gram-négatif. Dans un autre mode de réalisation, l'invention concerne des procédés pour inhiber une sécrétion de protéine de type III et/ou pour traiter et prévenir des infections bactériennes, en particulier des infections bactériennes à gram-négatif au moyen desdits composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)