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1. (WO2005113518) PROCESS FOR PREPARING IRBESARTAN
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/113518    International Application No.:    PCT/US2005/017953
Publication Date: 01.12.2005 International Filing Date: 20.05.2005
IPC:
C07D 257/00 (2006.01)
Applicants: DR. REDDY'S LABORATORIES LTD. [IN/IN]; 7-1-27 Ameerpet, Hyderabad 500 016 (IN) (For All Designated States Except US).
DR. REDDY'S LABORATORIES, INC. [US/US]; 200 Somerset Corporate Boulevard, 7th floor, Bridgewater, New Jersey 08807 (US) (For All Designated States Except US).
REDDY, Reguri Buchi [IN/IN]; (IN) (For US Only).
SUDHAKAR, Sunkari [IN/IN]; (IN) (For US Only).
SRIDHAR, Chaganti [IN/IN]; (IN) (For US Only).
RAO, Somisetti Narender [IN/IN]; (IN) (For US Only).
VENKATARAMAN, Sundaram [IN/IN]; (IN) (For US Only).
REDDY, Padi Pratap [IN/IN]; (IN) (For US Only).
SATYANARAYANA, Bollikonda [IN/IN]; (IN) (For US Only)
Inventors: REDDY, Reguri Buchi; (IN).
SUDHAKAR, Sunkari; (IN).
SRIDHAR, Chaganti; (IN).
RAO, Somisetti Narender; (IN).
VENKATARAMAN, Sundaram; (IN).
REDDY, Padi Pratap; (IN).
SATYANARAYANA, Bollikonda; (IN)
Agent: FRANKS, Robert, A.; Dr. Reddy's Laboratories, Inc., Patent Prosecution Group, 200 Somerset Corporate Boulevard 7th floor, Bridgewater, New Jersey 08807 (US)
Priority Data:
472/CHE/2004 20.05.2004 IN
60/579,914 15.06.2004 US
Title (EN) PROCESS FOR PREPARING IRBESARTAN
(FR) PROCESSUS POUR PRÉPARER DE L'IRBÉSARTAN
Abstract: front page image
(EN)A process for preparing irbesartan comprises pentanoylation of cycloleucine in the presence of sodium hydroxide to form n-pentanoyl cycloleucine, condensing this product with 2-(4-aminomethyl phenyl) benzonitrile using dicyclohexyl carbodiimide and 1-hydroxy benzotriazole as a catalyst to form the 4-(?-N-pentanoyl amino) cyclopentamido methyl-2'-cyano biphenyl compound, and then cyclizing using trifluroacetic acid in the presence of an aromatic solvent to form cyano irbesartan. Cyano irbesartan is converted to irbesartan by reaction with tributyltin chloride and sodium azide in the presence of an aromatic solvent.
(FR)Un processus pour préparer de l'irbésartan comprend une pentanoylation de cyclocleucine en présence d'hydroxyde de sodium pour former de la n-pentanoylcycloleucine, la condensation de ce produit avec du nitrile 2-(4-aminométhylphényle) benzoïque en utilisant du dicyclohexylcarbodiimide et du 1-hydroxybenzotriazole comme catalyseur pour former le composé 4-(?-N-pentanoylamino) cyclopentamidométhyl-2'-cyano biphényle, et le rendant cyclique par utilisation d'acide trifluoroacétique en présence d'un solvant aromatique pour former du cyano-irbésartan. Le cyano-irbésartan est converti en irbésartan par réaction avec le chlorure de tributyltine et l'azoture de sodium en présence d'un solvant aromatique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)