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1. (WO2005113515) PYRIMIDINES FOR USE AS PLK INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/113515    International Application No.:    PCT/EP2005/052214
Publication Date: 01.12.2005 International Filing Date: 13.05.2005
IPC:
C07D 239/48 (2006.01), A61K 31/505 (2006.01), A61P 29/00 (2006.01), A61P 31/12 (2006.01), A61P 35/00 (2006.01), A61P 37/00 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; CD Patents, Binger Strasse 173, 55216 INGELHEIM (DE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG [DE/DE]; CD Patents, Binger Strasse 173, 55216 INGELHEIM (DE) (DE only).
STADTMUELLER, Heinz [DE/AT]; (AT) (For US Only).
ENGELHARDT, Harald [DE/AT]; (AT) (For US Only).
REISER, Ulrich [DE/AT]; (AT) (For US Only).
ZAHN, Stephan, Karl [DE/AT]; (AT) (For US Only).
HAUPTMANN, Rudolf [AT/AT]; (AT) (For US Only).
STEEGMAIER, Martin [DE/DE]; (DE) (For US Only).
GUERTLER, Ulrich [DE/AT]; (AT) (For US Only).
HOFFMANN, Matthias [DE/DE]; (DE) (For US Only).
GRAUERT, Matthias [DE/DE]; (DE) (For US Only)
Inventors: STADTMUELLER, Heinz; (AT).
ENGELHARDT, Harald; (AT).
REISER, Ulrich; (AT).
ZAHN, Stephan, Karl; (AT).
HAUPTMANN, Rudolf; (AT).
STEEGMAIER, Martin; (DE).
GUERTLER, Ulrich; (AT).
HOFFMANN, Matthias; (DE).
GRAUERT, Matthias; (DE)
Agent: HAMMANN, Heinz; Postfach 200, 55216 INGELHEIM AM RHEIN (DE)
Priority Data:
04011911.7 19.05.2004 EP
Title (DE) PYRIMIDINE ALS PLK INHIBITOREN
(EN) PYRIMIDINES FOR USE AS PLK INHIBITORS
(FR) PYRIMIDINES COMME INHIBITEURS DE PLK
Abstract: front page image
(DE)Die vorliegende Erfindung umfasst Verbindungen der allgemeinen Formel (1), worin A, X, Y, Z, Ra, Rb, Rc, R1, R2 und R3 wie in Anspruch 1 definiert sind, welche zur Behandlung von Krankheiten, die durch exzessive oder anomale Zellproliferation charakterisiert sind, geeignet sind, sowie deren Verwendung zur Herstellung eines Arzneimittels mit den vorstehend genannten Eigenschaften.
(EN)The invention relates to the compounds of formula (1), wherein A, X, Y, Z, Ra, Rb, Rc, R1, R2 and R3 are defined as in claim 1. These compounds are suitable for use in the treatment of diseases which are characterized by excessive or abnormal cell proliferation. The invention also relates to the use of these compounds in the production of a drug having the above-mentioned properties.
(FR)L'invention concerne des composés de formule (1), dans laquelle A, X, Y, Z, Ra, Rb, Rc, R1, R2 et R3 sont tels que définis à la revendication 1. Ces composés sont destinés au traitement de maladies caractérisées par une prolifération cellulaire anormale ou excessive. La présente invention porte également sur l'utilisation de ces composés pour réaliser un médicament présentant les propriétés susmentionnées.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)