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1. (WO2005113509) NOVEL 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS HIV INTEGRASE INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/113509    International Application No.:    PCT/JP2005/009718
Publication Date: 01.12.2005 International Filing Date: 20.05.2005
IPC:
C07D 215/56 (2006.01), C07D 498/06 (2006.01), C07D 491/04 (2006.01), A61K 31/4741 (2006.01), A61P 31/18 (2006.01), C07D 405/06 (2006.01), C07D 401/06 (2006.01), C07D 401/04 (2006.01)
Applicants: JAPAN TOBACCO INC. [JP/JP]; 2-1, Toranomon 2-chome, Minato-ku, Tokyo, 1058422 (JP) (For All Designated States Except US).
SATOH, Motohide [JP/JP]; (JP) (For US Only).
MATSUDA, Takashi [JP/JP]; (JP) (For US Only).
OKUDA, Satoshi [JP/JP]; (JP) (For US Only).
KAWAKAMI, Hiroshi [JP/JP]; (JP) (For US Only).
ARAMAKI, Hisateru [JP/JP]; (JP) (For US Only).
SHINKAI, Hisashi [JP/JP]; (JP) (For US Only).
MATSUZAKI, Yuji [JP/JP]; (JP) (For US Only).
WATANABE, Wataru [JP/JP]; (JP) (For US Only).
YAMATAKA, Kazunobu [JP/JP]; (JP) (For US Only).
KIYONARI, Shinichi [JP/JP]; (JP) (For US Only).
WAMAKI, Shuichi [JP/JP]; (JP) (For US Only).
TAKAHASHI, Mitsuru [JP/JP]; (JP) (For US Only).
YAMADA, Naohito [JP/JP]; (JP) (For US Only).
NAGAO, Akemi [JP/JP]; (JP) (For US Only)
Inventors: SATOH, Motohide; (JP).
MATSUDA, Takashi; (JP).
OKUDA, Satoshi; (JP).
KAWAKAMI, Hiroshi; (JP).
ARAMAKI, Hisateru; (JP).
SHINKAI, Hisashi; (JP).
MATSUZAKI, Yuji; (JP).
WATANABE, Wataru; (JP).
YAMATAKA, Kazunobu; (JP).
KIYONARI, Shinichi; (JP).
WAMAKI, Shuichi; (JP).
TAKAHASHI, Mitsuru; (JP).
YAMADA, Naohito; (JP).
NAGAO, Akemi; (JP)
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka, 5410044 (JP)
Priority Data:
2004-151034 20.05.2004 JP
Title (EN) NOVEL 4-OXOQUINOLINE COMPOUND AND USE THEREOF AS HIV INTEGRASE INHIBITOR
(FR) NOUVEAU COMPOSÉ 4-OXOQUINOLINE ET UTILISATION DE CELUI-CI COMME INHIBITEUR D'INTÉGRASE DE VIH
Abstract: front page image
(EN)Provision of a compound having an anti-HIV activity, particularly an integrase inhibitory activity.A 4-oxoquinoline compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification.The present invention also relates to a pharmaceutical composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; an integrase inhibitor, an antiviral agent, anti-HIV agent and the like, which contains the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient; an anti-HIV composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and one or more other kinds of anti-HIV activity substances as active ingredients; an anti-HIV agent containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient, which is used for a multiple drug therapy with other anti-HIV agent(s), and the like.
(FR)Fourniture d'un composé ayant une activité anti-VIH, en particulier une activité inhibitrice d'intégrase. Composé 4-oxoquinoline représenté par la formule [I] suivante ou sel acceptable du point de vue pharmaceutique de celui-ci : dans laquelle chaque symbole est tel que défini dans la description. La présente invention concerne également une composition pharmaceutique contenant le composé 4-oxoquinoline ou un sel acceptable du point de vue pharmaceutique de celui-ci et un véhicule acceptable du point de vue pharmaceutique ; un inhibiteur d'intégrase, un agent antiviral, un agent anti-VIH et similaire, lesquels contiennent le composé 4-oxoquinoline ou un sel acceptable du point de vue pharmaceutique de celui-ci comme ingrédient actif ; une composition anti-VIH contenant le composé 4-oxoquinoline ou un sel acceptable du point de vue pharmaceutique de celui-ci et une ou plusieurs autres sortes de substances à activité anti-VIH comme ingrédients actifs ; un agent anti-VIH contenant le composé 4-oxoquinoline ou un sel acceptable du point de vue pharmaceutique de celui-ci comme ingrédient actif, lequel est utilisé pour une multithérapie avec un ou plusieurs autres agents anti-VIH, et similaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)