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Machine translation
1. (WO2005112919) SELF-IMMOLATIVE LINKERS AND DRUG CONJUGATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/112919    International Application No.:    PCT/US2005/017804
Publication Date: 01.12.2005 International Filing Date: 19.05.2005
IPC:
A61K 47/48 (2006.01), A61P 35/00 (2006.01)
Applicants: MEDAREX, INC. [US/US]; 707 State Road, Princeton, NJ 08540 (US) (For All Designated States Except US).
BOYD, Sharon [US/US]; (US) (For US Only).
CHEN, Liang [US/US]; (US) (For US Only).
GANGWAR, Sanjeev [US/US]; (US) (For US Only).
GUERLAVAIS, Vincent [FR/US]; (US) (For US Only).
HORGAN, Kilian [IE/US]; (US) (For US Only).
LI, Zhi-Hong [CN/US]; (US) (For US Only).
SUFI, Bilal [PK/US]; (US) (For US Only)
Inventors: BOYD, Sharon; (US).
CHEN, Liang; (US).
GANGWAR, Sanjeev; (US).
GUERLAVAIS, Vincent; (US).
HORGAN, Kilian; (US).
LI, Zhi-Hong; (US).
SUFI, Bilal; (US)
Agent: FEHLNER, Paul, F.; Darby & Darby, P.C., P.O. Box 5257, New York, NY 10150-5257 (US)
Priority Data:
60/572,667 19.05.2004 US
60/661,174 09.03.2005 US
60/669,871 08.04.2005 US
Title (EN) SELF-IMMOLATIVE LINKERS AND DRUG CONJUGATES
(FR) BRAS DE LIAISON CHIMIQUES ET CONJUGUES ASSOCIES
Abstract: front page image
(EN)The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine or disulfide self-immolative linker. In a particular embodiment the cytotoxin is represented by duocarmycins and derivatives thereof. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them.
(FR)L'invention concerne des conjugués médicaments-ligands qui constituent de puissantes cytotoxines. Le médicament est lié au ligand à l'aide d'un bras de liaison peptidyle, hydrazine, ou disulfure. L'invention concerne par ailleurs des compositions qui renferment les conjugués médicaments-ligants, ainsi que des méthodes de traitement qui font intervenir ces conjugués.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)