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1. (WO2005112885) OLIGONUCLEOTIDE-CONTAINING MICROSPHERES, THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING DIABETES TYPE 1
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/112885    International Application No.:    PCT/US2005/016689
Publication Date: 01.12.2005 International Filing Date: 12.05.2005
IPC:
A61K 9/16 (2006.01), A61K 38/00 (2006.01), A61K 39/00 (2006.01)
Applicants: BAXTER INTERNATIONAL INC. [US/US]; One Baxter Parkway, DF2-2W, Deerfield, IL 60015 (US) (For All Designated States Except US).
BAXTER HEALTHCARE S.A. [CH/CH]; Heristrasse 2, CH-8304 Wallisellen (CH) (For All Designated States Except US).
CHILDREN'S HOSPITAL OF PITTSBURGH [US/US]; 3705 Fifth Avenue, Pittsburgh, PA 15213 (US) (For All Designated States Except US).
SCOTT, Terrence, L. [US/US]; (US) (For US Only).
LAFRENIERE, Debra [US/US]; (US) (For US Only).
GIANNOUKAKIS, Nick [US/US]; (US) (For US Only).
BISKER-LEIB, Vered [US/US]; (US) (For US Only).
BROWN, Larry, R. [US/US]; (US) (For US Only).
MACHEN, Jennifer [US/US]; (US) (For US Only)
Inventors: SCOTT, Terrence, L.; (US).
LAFRENIERE, Debra; (US).
GIANNOUKAKIS, Nick; (US).
BISKER-LEIB, Vered; (US).
BROWN, Larry, R.; (US).
MACHEN, Jennifer; (US)
Agent: MEHLER, Raymond, M.; Cook, Alex, McFarron, Manzo, Cummings & Mehler, Ltd., Suite 2850, 200 West Adams Street, Chicago, IL 60606 (US)
Priority Data:
60/570,273 12.05.2004 US
60/625,483 05.11.2004 US
Title (EN) OLIGONUCLEOTIDE-CONTAINING MICROSPHERES, THEIR USE FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATING DIABETES TYPE 1
(FR) ADMINISTRATION DE MICROSPHERES D'OLIGONUCLEOTIDES ANTISENS POUR INDUIRE UNE TOLERANCE DE CELLULES DENDRITIQUES POUR LE TRAITEMENT DU DIABETE DE TYPE 1 INSULINO-DEPENDANT
Abstract: front page image
(EN)This application refers to microspheres comprising oligonucleotides for treatment of type 1 diabetes, said oligonucleotides comprise between about 30 weight percent and about 100 weight percent of the microspheres, based on the total weight of the microspheres, said microspheres having an average particle size of not greater than about 50 microns. The oligonucleotides are targeted to bind to primary transcripts selected from the group consisting of CD40, CD80 and CD86 primary transcripts, and combinations thereof.
(FR)Selon cette invention, des oligonucléotides antisens sont administrés sous forme de microsphères afin d'induire la tolérance de cellules dendritiques, plus spécifiquement dans le modèle de souris non obèse diabétique (NOD). Ces microsphères comprennent des oligonucléotides antisens (AS). L'invention concerne également un procédé consistant à mettre en oeuvre une approche antisens pour empêcher un état de diabète insulino-dépendant dans des souris NOD in vivo et in situ. Les oligonucléotides sont ciblés pour se lier à des transcrits primaires CD40, CD80, CD86 et aux combinaisons de ceux-ci.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)