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1. (WO2005111204) PORCINE FORSSMAN SYNTHETASE CDNA AND POLYPEPTIDE

Pub. No.:    WO/2005/111204    International Application No.:    PCT/US2005/016347
Publication Date: Nov 24, 2005 International Filing Date: May 9, 2005
IPC: C12P 21/06
C12N 9/00
C12N 15/70
C12N 5/16
Applicants: UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
KOIKE, Chihiro
Inventors: KOIKE, Chihiro
Title: PORCINE FORSSMAN SYNTHETASE CDNA AND POLYPEPTIDE
Abstract:
The present invention provides porcine Forssman synthetase (FSM snythase) (Globoside α-N-acetylgalactosaminyltransferase) protein, cDNA, and genomic DNA sequence. Furthermore, the present invention includes porcine animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional FSM synthetase. Such animals, tissues, organs and cells can be used in research and in medical therapy, including in xenotransplantation. In addition, methods are provided to prepare organs, tissues, and cells lacking the porcine FSM synthetase gene for use in xenotransplantation.