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1. (WO2005110399) ZINC-BINDING GROUPS FOR METALLOPROTEIN INHIBITORS

Pub. No.:    WO/2005/110399    International Application No.:    PCT/US2005/009277
Publication Date: Nov 24, 2005 International Filing Date: Mar 21, 2005
IPC: A61K 31/35
A61K 31/435
A61K 31/167
A61P 35/00
C07D 309/38
C07D 213/69
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
PUERTA, David, T.
COHEN, Seth, M.
LEWIS, Jana, A.
Inventors: PUERTA, David, T.
COHEN, Seth, M.
LEWIS, Jana, A.
Title: ZINC-BINDING GROUPS FOR METALLOPROTEIN INHIBITORS
Abstract:
The present invention relates to metalloprotein inhibitors comprising: a. an organic backbone molecule (Pep) and at least one zinc binding group (ZBG) covalently attached thereto; or b. at least one ZBG substituted by a side chain that comprises one or more amido and/or amino moieties, wherein the ZBG is of formula (I): wherein the wavy line represents a Pep molecule or a side chain that is an R3 or an R4 group which comprises one or more amido and/or amino moieties, and wherein X is O or S and each R1, R2, R3, and R4 is individually hydrogen or an organic radical. The metalloprotein inhibitors are useful for preventing or treating a pathological disease, condition, or symptom that is associated with pathological metalloprotein activity and/or that is alleviated by inhibition of said activity.