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Machine translation
1. (WO2005108610) METHODS FOR THE SELECTION OF SUBJECTS FOR MULTIPLE SCLEROSIS THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/108610    International Application No.:    PCT/US2004/010584
Publication Date: 17.11.2005 International Filing Date: 05.04.2004
IPC:
C12Q 1/68 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA as REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer, Suite 325, 6011 Executive Boulevard, Rockville, MD 20852-3804 (US) (For All Designated States Except US).
MARTIN, Roland [DE/US]; (US) (For US Only).
STÜRZEBECHER, Claus-Steffen [DE/DE]; (DE) (For US Only).
STAUDT, Louis, M. [US/US]; (US) (For US Only).
MCFARLAND, Henry [US/US]; (US) (For US Only)
Inventors: MARTIN, Roland; (US).
STÜRZEBECHER, Claus-Steffen; (DE).
STAUDT, Louis, M.; (US).
MCFARLAND, Henry; (US)
Agent: SIEGEL, Susan, Alpert; Klarquist, Sparkman, LLP, One World Trade Center, Suite 1600, 121 SW Salmon Street, Portland, OR 97204 (US)
Priority Data:
Title (EN) METHODS FOR THE SELECTION OF SUBJECTS FOR MULTIPLE SCLEROSIS THERAPY
(FR) PROCEDES DE SELECTION DE SUJETS POUR UN TRAITEMENT DE LA SCLEROSE EN PLAQUES
Abstract: front page image
(EN)A variety of therapies are used to treat autoimmune diseases such as multiple sclerosis. However, there is no single therapy that can be used to treat all subjects. Thus, a method is provided to determine if a subject with an autoimmune disease, such as multiple sclerosis, will respond to a therapeutic protocol. The method includes analyzing the expression of genes expressed by the immune system. Although the expression of a single gene can be assessed, such as interleukin-8, the methods include evaluating the expression profile of a subject using an array (such as a microarray) to determine if the subject is appropriately responding to the therapeutic protocol.
(FR)Diverses thérapies sont utilisées pour traiter des maladies auto-immunes telles que la sclérose en plaques. Cependant, aucune thérapie unique n'est applicable à tous les sujets. L'invention concerne un procédé permettant de déterminer si un sujet atteint d'une maladie auto-immune telle que la sclérose en plaques, répondra à un protocole thérapeutique. Le procédé comprend l'analyse de l'expression des gènes exprimés par le système immunitaire. Bien qu'il soit possible d'évaluer l'expression d'un seul gène, p. ex. l'interleukine-8, les procédés comprennent l'évaluation, au moyen d'un réseau (p. ex. microréseau), du profil d'expression du sujet pour déterminer si celui-ci répond de façon appropriée au protocole thérapeutique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)