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1. (WO2005108605) POLYMORPHISMS IN ABCB1 ASSOCIATED WITH A LACK OF CLINICAL RESPONSE TO MEDICAMENTS

Pub. No.:    WO/2005/108605    International Application No.:    PCT/EP2005/005194
Publication Date: Nov 17, 2005 International Filing Date: May 12, 2005
IPC: C12Q 1/68
Applicants: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN
UHR, Manfred
HOLSBOER, Florian
BINDER, Elisabeth
MÜLLER-MYHSOK, Bertram
Inventors: UHR, Manfred
HOLSBOER, Florian
BINDER, Elisabeth
MÜLLER-MYHSOK, Bertram
Title: POLYMORPHISMS IN ABCB1 ASSOCIATED WITH A LACK OF CLINICAL RESPONSE TO MEDICAMENTS
Abstract:
The present invention relates to methods, compositions and kits for determining the prognosis of a clinical response in a human patient to a medicament which acts in the central nervous system and which is a substrate of the ABCB1 protein. Further, the invention relates to a combination of medicaments for the treatment of human patients having specific polymorphisms in the ABCB1 gene.