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1. (WO2005108592) PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE PROPARGYL ALCOHOL

Pub. No.:    WO/2005/108592    International Application No.:    PCT/JP2005/009016
Publication Date: Nov 17, 2005 International Filing Date: May 11, 2005
IPC: C12N 15/09
C12P 7/02
Applicants: TAISHO PHARMACEUTICAL CO., LTD.
大正製薬株式会社
YAMAMOTO, Hiroaki
山本 浩明
KUDOH, Masatake
工藤 眞丈
HAYASHI, Motoko
林 素子
Inventors: YAMAMOTO, Hiroaki
山本 浩明
KUDOH, Masatake
工藤 眞丈
HAYASHI, Motoko
林 素子
Title: PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE PROPARGYL ALCOHOL
Abstract:
The invention provides a process for the production of optically active propargyl alcohol useful as an intermediate in the synthesis of drugs. According to the invention, optically active propargyl alcohol is produced by asymmetric reduction of propargyl ketone with a secondary alcohol dehydrogenase or a carbonyl reductase.