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1. (WO2005108394) PROCESS FOR THE PREPARATION OF ROSIGLITAZONE

Pub. No.:    WO/2005/108394    International Application No.:    PCT/EP2004/005098
Publication Date: Nov 17, 2005 International Filing Date: May 12, 2004
IPC: C07D 417/12
Applicants: MEDICHEM S.A.
DURAN LÓPEZ, Ernesto
TOJO SUÁREZ, Gabriel
Inventors: DURAN LÓPEZ, Ernesto
TOJO SUÁREZ, Gabriel
Title: PROCESS FOR THE PREPARATION OF ROSIGLITAZONE
Abstract:
The present invention relates to a process for the preparation of 5-{4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl-2,4-thiazolidinedione of formula (I) (Rosiglitazone), which comprises the reaction of 5-{4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxyl]benzylidene-2,4-thiazolidinedione of formula (II), with a 1,4-dihydropyridine of general formula (III).