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1. WO2005108375 - PROCESS FOR THE PREPARATION OF TELMISARTAN

Publication Number WO/2005/108375
Publication Date 17.11.2005
International Application No. PCT/GB2005/001799
International Filing Date 10.05.2005
Chapter 2 Demand Filed 09.03.2006
IPC
A61K 31/4184 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4184condensed with carbocyclic rings, e.g. benzimidazoles
C07D 235/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
04Benzimidazoles; Hydrogenated benzimidazoles
18with aryl radicals directly attached in position 2
CPC
A61P 9/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
A61P 9/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A61P 9/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
C07D 235/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
235Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
02condensed with carbocyclic rings or ring systems
04Benzimidazoles; Hydrogenated benzimidazoles
20Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
Applicants
  • CIPLA LIMITED [IN]/[IN] (AllExceptUS)
  • TURNER, Craig, Robert [GB]/[GB] (MW)
  • KANKAN, Rajendra, Narayanrao [IN]/[IN] (UsOnly)
  • RAO, Dharmaraj, Ramachandra [IN]/[IN] (UsOnly)
  • SRINIVAS, Pathi, L. [IN]/[IN] (UsOnly)
  • RAVIKUMAR, Puppala [IN]/[IN] (UsOnly)
Inventors
  • KANKAN, Rajendra, Narayanrao
  • RAO, Dharmaraj, Ramachandra
  • SRINIVAS, Pathi, L.
  • RAVIKUMAR, Puppala
Agents
  • TURNER, Craig, Robert
Priority Data
0410471.711.05.2004GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PREPARATION OF TELMISARTAN
(FR) PREPARATION DE TELMISARTAN
Abstract
(EN)
An improved process for the preparation of telmisartan, or a pharmaceutically acceptable salt thereof, comprises subjecting 1H-Benzimidazole-2-n-propyl-4-methyl-6-(1'-methyl benimidazole-2'yl) of formula (II) and methyl-4-(bromomethyl) biphenyl-2-carboxylate of formula (III) to condensation and hydrolysis in a single step.
(FR)
Procédé de fabrication amélioré de telmisartan, ou d'un sel pharmaceutiquement acceptable de cette substance, consistant à soumettre ) à condensation et hydrolyse en une seule opération un 1H-benzimidazole-2-n-propyl-4-méthyl-6-(1'-méthyl benimidazole-2'yl) représenté par la formule (II) et un méthyl-4-(bromométhyl) biphényl-2-carboxylate représenté par la formule (III).
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