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Machine translation
1. (WO2005108338) NOVEL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER, METABOLIC DISEASES AND SKIN DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/108338    International Application No.:    PCT/US2005/015366
Publication Date: 17.11.2005 International Filing Date: 02.05.2005
IPC:
A61K 31/12 (2006.01), A61K 31/165 (2006.01), A61K 31/35 (2006.01), C07C 49/115 (2006.01), C07C 49/23 (2006.01), C07C 49/76 (2006.01), C07C 233/00 (2006.01), C07D 311/78 (2006.01), C07D 335/04 (2006.01)
Applicants: AUSPEX PHARMACEUTICALS [US/US]; 1261 Liberty Way, Suite C, Vista, CA 92083 (US) (For All Designated States Except US).
SARSHAR, Sepehr [US/US]; (US) (For US Only)
Inventors: SARSHAR, Sepehr; (US)
Agent: HAILE, Lisa, A.; DLA Piper Rudnick Gray Cary US LLP, 4365 Executive Drive, Suite 1100, San Diego, CA 92121-2133 (US)
Priority Data:
60/567,965 03.05.2004 US
Title (EN) NOVEL THERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER, METABOLIC DISEASES AND SKIN DISORDERS
(FR) AGENTS THERAPEUTIQUES POUR LE TRAITEMENT DU CANCER, DES MALADIES METABOLIQUES ET DE LA PEAU
Abstract: front page image
(EN)The present invention is directed to novel compounds according to formulae (I) wherein R1, R2, R3 and R4 are as defined herein. The invention also discloses methods of preparation, pharmaceutical compositions, and methods of disease treatment utilizing pharmaceutical compositions comprising these compounds. The compounds of this invention are novel therapeutic agents for the treatment of cancer, diabetes, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals.
(FR)L'invention concerne des composés représentés par les formules (I), sachant que R1, R2, R3 et R4 sont tels que définis dans la description. L'invention concerne également des procédés d'élaboration, des compositions pharmaceutiques et des procédés de traitement de maladie reposant sur des compositions pharmaceutiques qui renferment les composés en question, lesquels constituent des agents thérapeutiques pour le traitement du cancer, du diabète, des maladies métaboliques et de la peau chez des sujets mammaliens, étant utiles par ailleurs comme modulateurs de l'expression génique. Les composés considérés agissent en interférant avec certaines cascades de transduction de signal cellulaire. Ils sont également utiles pour la régulation de la différenciation cellulaire et les processus de cycle cellulaire contrôlés ou régulés par diverses hormones ou cytokines. L'invention concerne enfin des compositions pharmaceutiques et des procédés de traitement de maladie chez les mammifères.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)