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1. (WO2005107827) NUCLEUS PULPOSUS FILLER

Pub. No.:    WO/2005/107827    International Application No.:    PCT/JP2005/008179
Publication Date: Nov 17, 2005 International Filing Date: Apr 28, 2005
IPC: A61L 27/00
Applicants: SEIKAGAKU CORPORATION
生化学工業株式会社
TAKAHASHI, Katsuya
高橋 勝哉
SATO, Tomoya
佐藤 倫也
MATSUYAMA, Yukihiro
松山 幸弘
Inventors: TAKAHASHI, Katsuya
高橋 勝哉
SATO, Tomoya
佐藤 倫也
MATSUYAMA, Yukihiro
松山 幸弘
Title: NUCLEUS PULPOSUS FILLER
Abstract:
It is intended to provide a nucleus pulposus filler or the like which is to be filled into an area in deformed intervertebral disc wherein normal nucleus should be located and can be stably held therein over a long time. More specifically speaking, a nucleus pulposus filler containing crosslinked chondroitin sulfate as the active ingredient. It is preferable that a photo crosslinked chondroitin sulfate is one obtained by freezing a photoreactive chondroitin sulfate-containing solution which contains photoreactive chondroitin sulfate having a photoreactive group attached thereto and an aqueous solvent in which the photoreactive chondroitin sulfate is soluble together with at least one substance selected from the group consisting of an alcohol miscible with the aqueous solvent, a surfactant and a chelating agent, then irradiating the frozen product with light and thus thawing the frozen product. This filler may be packed in a container from which it can be pushed out and provided in the form of a kit.