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1. (WO2005107820) COMPOSITIONS AND METHODS FOR ENHANCING CONTRAST IN IMAGING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/107820    International Application No.:    PCT/US2005/000876
Publication Date: 17.11.2005 International Filing Date: 12.01.2005
IPC:
A61K 9/127 (2006.01), A61K 49/00 (2006.01), A61K 49/04 (2006.01), A61K 51/00 (2006.01)
Applicants: MARVEL THERAPEUTICS [US/US]; 3114 Spring Ridge Drive, Manvel, TX 77578 (US) (For All Designated States Except US).
ANNAPRAGADA, Ananth [IN/US]; (US) (For US Only).
BELLAMKONDA, Ravi, V. [IN/US]; (US) (For US Only).
HOFFMAN, Eric [US/US]; (US) (For US Only).
VIJAYALAKSHMI, Chandra [IN/US]; (US) (For US Only).
KAO, Chen-Yu [--/US]; (US) (For US Only).
GHAGHADA, Ketan [IN/US]; (US) (For US Only)
Inventors: ANNAPRAGADA, Ananth; (US).
BELLAMKONDA, Ravi, V.; (US).
HOFFMAN, Eric; (US).
VIJAYALAKSHMI, Chandra; (US).
KAO, Chen-Yu; (US).
GHAGHADA, Ketan; (US)
Agent: SLADEK, Todd, L.; Benesch, Friedlander, Coplan & Aronoff LLP, 2300 BP Tower, 200 Public Square, Cleveland, OH 44114 (US)
Priority Data:
10/830,190 21.04.2004 US
Title (EN) COMPOSITIONS AND METHODS FOR ENHANCING CONTRAST IN IMAGING
(FR) COMPOSITIONS ET PROCEDES PERMETTANT D'AMELIORER LE CONTRASTE EN IMAGERIE
Abstract: front page image
(EN)Example compositions of liposomes with hydrophilic polymers on their surface, and containing relatively high concentrations of contrast-enhancing agents for computed tomography are provided. Example pharmaceutical compositions of such liposomes, when administered to a subject, provide for increased contrast of extended duration, as measured by computed tomography, in the bloodstream and other tissues of the subject. Also provided are example methods for making the liposomes containing high concentrations of contrast­-enhancing agents, and example methods for using the compositions.
(FR)Aux fins de l'invention, on donne des compositions de liposomes comportant en surface des polymères hydrophiles et présentant des concentrations relativement élevées d'agents augmentant le contraste pour la tomographie par ordinateur, et lorsque ces compositions pharmaceutiques de liposomes sont administrées à un sujet, on améliore le contraste sur une durée étendue, selon les mesures effectuées en tomographie par ordinateur, dans le système circulatoire et autres tissus chez le sujet. L'invention concerne également des exemples de procédés qui permettent d'élaborer les liposomes à concentrations élevées d'agents augmentant le contraste, et des procédés relatifs à l'utilisation des compositions correspondantes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)