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1. (WO2005107714) METHOD OF FORMING MICROPARTICLES THAT INCLUDE A BISPHOSPHONATE AND A POLYMER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/107714    International Application No.:    PCT/US2005/015757
Publication Date: 17.11.2005 International Filing Date: 05.05.2005
IPC:
A61K 9/16 (2006.01)
Applicants: ALKERMES CONTROLLED THERAPEUTICS, INC. [US/US]; 88 Sidney Street, 2nd Floor, Cambridge, MA 02139 (US) (For All Designated States Except US).
FIGUEIREDO, Maria, C. [US/US]; (US) (For US Only).
KUMAR, Rajesh [IN/US]; (US) (For US Only).
MALONEY, Maura, J. [US/US]; (US) (For US Only).
SCHER, David, S. [US/US]; (US) (For US Only).
YEOH, Thean, Y. [MY/US]; (US) (For US Only).
ZALE, Stephen, E. [US/US]; (US) (For US Only).
PRINN, Kristin [US/US]; (US) (For US Only).
TROIANO, Gregory [US/US]; (US) (For US Only)
Inventors: FIGUEIREDO, Maria, C.; (US).
KUMAR, Rajesh; (US).
MALONEY, Maura, J.; (US).
SCHER, David, S.; (US).
YEOH, Thean, Y.; (US).
ZALE, Stephen, E.; (US).
PRINN, Kristin; (US).
TROIANO, Gregory; (US)
Agent: PIERCE, Scott, N.; Hamilton, Brook, Smith & Reynolds, P.C., 530 Virginia Road, P.O. Box 9133, Concord, MA 01742-9133 (US)
Priority Data:
60/568,467 05.05.2004 US
Title (EN) METHOD OF FORMING MICROPARTICLES THAT INCLUDE A BISPHOSPHONATE AND A POLYMER
(FR) PROCEDE DE FORMATION DE MICROPARTICULES COMPORTANT UN BISPHOSPHONATE ET UN POLYMERE
Abstract: front page image
(EN)Microparticles that includes a bisphosphonate and a polymer are produced by a method that includes forming a water-in-oil emulsion by mixing an aqueous solution of the bisphosphonate with a combination of a biocompatible polymer and a polymer solvent. At least one aqueous liquid can be mixed with the water-in-oil emulsion to form a water-in-oil-in-water emulsion and to extract the polymer solvent from the polymer, thereby forming the microparticles. Methods of treating a patient in need of therapy include administering the microparticles described to the patient. In one embodiment, the microparticles are formulated for the sustained release of the bisphosphonate.
(FR)La présente invention a trait à un procédé de production de microparticules comportant un bisphosphonate et un polymère comprenant la formation d'une émulsion eau dans huile par le mélange d'une solution aqueuse de bisphosphonate avec une combinaison d'un polymère biocompatible et un solvant de polymère. Au moins un liquide aqueux peut être mélangé avec l'émulsion eau dans huile pour la formation d'une émulsion eau dans huile et l'extraction du solvant de polymère du polymère, formant ainsi les microparticules. L'invention a également trait à des procédés de traitement d'un patient nécessitant une thérapie comprenant l'administration desdites microparticules au patient. Dans un mode de réalisation, les microparticules sont formulées pour la libération prolongée du bisphosphonate.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)