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1. (WO2005106493) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED APELIN RECEPTOR (APJ)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/106493    International Application No.:    PCT/EP2005/004110
Publication Date: 10.11.2005 International Filing Date: 18.04.2005
IPC:
A61K 38/04 (2006.01), A61K 39/00 (2006.01), A61K 39/395 (2006.01), A61K 48/00 (2006.01), G01N 33/50 (2006.01)
Applicants: BAYER HEALTHCARE AG [DE/DE]; 51368 Leverkusen (DE) (For All Designated States Except US).
GOLZ, Stefan [DE/DE]; (DE) (For US Only).
BRÜGGEMEIER, Ulf [DE/DE]; (DE) (For US Only).
GEERTS, Andreas [DE/DE]; (DE) (For US Only).
SUMMER, Holger [DE/DE]; (DE) (For US Only)
Inventors: GOLZ, Stefan; (DE).
BRÜGGEMEIER, Ulf; (DE).
GEERTS, Andreas; (DE).
SUMMER, Holger; (DE)
Common
Representative:
BAYER HEALTHCARE AG; Law and Patents, Patents and Licensing, 51368 Leverkusen (DE)
Priority Data:
04010390.5 30.04.2004 EP
Title (EN) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED APELIN RECEPTOR (APJ)
(FR) DIAGNOSTICS ET THERAPIES POUR MALADIES ASSOCIEES AU RECEPTEUR DE L'APELINE COUPLEE A UNE PROTEINE G (APJ)
Abstract: front page image
(EN)The invention provides a human APJ which is associated with the cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, hematological disorders, respiratory diseases, muscle-skeleton disorders, neurological disorders, urological disorders, dermatological diseases and reproduction disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, endocrine system and hormone disorders, metabolic diseases, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, hematological disorders, respiratory diseases, muscle-skeleton disorders, neurological disorders, urological disorders, dermatological diseases and reproduction disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of APJ as well as pharmaceutical compositions comprising such compounds.
(FR)Un APJ humain associé à des troubles cardio-vasculaires, au système endocrinien et aux troubles hormonaux, aux maladies métaboliques, aux maladies gastro-intestinales et hépatiques, aux troubles cancéreux, aux maladies inflammatoires, aux troubles hématologiques, aux maladies respiratoires, aux troubles des muscles et du squelette, aux troubles neurologiques, aux troubles urologiques, aux maladies dermatologiques et aux troubles de la reproduction. Des essais d'identification de composés utiles dans le traitement ou la prévention de troubles cardio-vasculaires, du système endocrinien et des troubles hormonaux, des maladies métaboliques, des maladies gastro-intestinales et hépatiques, des troubles cancéreux, des maladies inflammatoires, des troubles hématologiques, des maladies respiratoires, des troubles des muscles et du squelette, des troubles neurologiques, des troubles urologiques, des maladies dermatologiques et des troubles de la reproduction. Des composés se liant et/ou activant ou inhibant l'activité de APJ, ainsi que des compositions pharmaceutiques renfermant de tels composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)