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Machine translation
1. (WO2005106011) PROCESS FOR PREPARING DIPEPTIDYL IV INHIBITORS AND INTERMEDIATES THEREFOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/106011    International Application No.:    PCT/US2005/012615
Publication Date: 10.11.2005 International Filing Date: 13.04.2005
IPC:
C07D 209/04 (2006.01), C12N 9/06 (2006.01), C12N 1/20 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road, Princeton, New Jersey 08543-4000 (US) (For All Designated States Except US).
POLITINO, Michael [US/US]; (US) (For US Only).
CADIN, Matthew M. [US/US]; (US) (For US Only).
SKONEZNY, Paul M. [US/US]; (US) (For US Only).
CHEN, Jason G. [CN/US]; (US) (For US Only)
Inventors: POLITINO, Michael; (US).
CADIN, Matthew M.; (US).
SKONEZNY, Paul M.; (US).
CHEN, Jason G.; (US)
Agent: RODNEY, Burton; Bristol-Myers Squibb Company, P.O. Box 4000, Princeton, New Jersey 08543-4000 (US)
Priority Data:
60/561,986 14.04.2004 US
Title (EN) PROCESS FOR PREPARING DIPEPTIDYL IV INHIBITORS AND INTERMEDIATES THEREFOR
(FR) PROCEDE DE PREPARATION D'INHIBITEURS DE LA DIPEPTIDYL PEPTIDASE IV ET DE LEURS INTERMEDIAIRES
Abstract: front page image
(EN)A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure (3) prepared by subjecting an acid of the structure (1) to reduce amination by treating the acid with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase/formate dehydrogenase enzyme concentrate (PDH/FDH) and without isolating treating the resulting amine of the structure (2) with di-tert-butyl dicarbonate to form the BOC-protected amine.
(FR)L'invention concerne un procédé de production d'inhibiteurs à base de pyrrolidine fusionnée à du cyclopropyle de dipeptidyl peptidase IV. Ce procédé fait appel à une amine de structure (3) protégée par BOC préparée par la soumission d'un acide de structure (1) pour réduire une amination par le traitement de l'acide avec du méthanoate d'ammonium, du dinucléotide de l'adénine nicotinamide, du dithiothréitol et du concentrat d'enzymes de déshydrogénase/méthanoate déshydrogénase de phénylalamine partiellement purifiée (PDH/FDH), et sans isolement, par le traitement de l'amine obtenue de structure (2) avec du bicarbonate de di-tert-butyle pour former l'amine protégée par BOC.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)