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1. (WO2005105784) DIASTEREOSELECTIVE SYNTHESIS PROCESS FOR THE PREPARATION OF IMIDAZOLE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/105784    International Application No.:    PCT/EP2005/051934
Publication Date: 10.11.2005 International Filing Date: 28.04.2005
IPC:
C07D 401/06 (2006.01)
Applicants: JANSSEN PHARMACEUTICA N.V. [BE/BE]; Turnhoutseweg 30, B-2340 Beerse (BE) (For All Designated States Except US).
FILLIERS, Walter, Ferdinand, Maria [BE/BE]; (BE) (For US Only).
BROECKX, Rudy, Laurent, Maria [BE/BE]; (BE) (For US Only).
ANGIBAUD, Patrick, René [FR/FR]; (FR) (For US Only)
Inventors: FILLIERS, Walter, Ferdinand, Maria; (BE).
BROECKX, Rudy, Laurent, Maria; (BE).
ANGIBAUD, Patrick, René; (FR)
Common
Representative:
JANSSEN PHARMACEUTICA N.V.; Turnhoutseweg 30, B-2340 Beerse (BE)
Priority Data:
04076319.5 03.05.2004 EP
Title (EN) DIASTEREOSELECTIVE SYNTHESIS PROCESS FOR THE PREPARATION OF IMIDAZOLE COMPOUNDS
(FR) PROCEDE DE SYNTHESE DIASTEREOSELECTIVE POUR LA PREPARATION DE COMPOSES IMIDAZOLE
Abstract: front page image
(EN)A diastereoselective synthesis process for the preparation of an enantiomer of 6-­[amino(4-chlorophenyl)(1-methyl-1 H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)- 1-­methyl-2(1H)-quinolinone which comprises the conversion of (±)-6-[chloro(4­-chlomphenyl)(I-methyl-lH-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl­2(IH)-quinolinone into a compound of formula (VIII) wherein aryl is phenyl substituted once or twice with C1-6alkyloxy or naphtalenyl substituted once or twice with Cl-6alkyloxy.
(FR)L'invention concerne un procédé de synthèse diastéréosélective pour la préparation d'un énantiomère de 6-[amino(4-chlorophényl)(1-méthyl-1H-imidazol-5-yl)méthyl]-4-(3-chlorophényl)-1-méthyl-2(1H)-quinolinone qui consiste à convertir du (±)-6-[chloro(4-chlorophényl)(I-méthyl-lH-imidazol-5-yl)méthyl]-4-(3-chlorophényl)-1-méthyl-2(IH)-quinolinone en un composé de formule générale (VIII) dans laquelle aryle est substitué par phényle une ou deux fois avec C1-6alkyloxy ou est substitué par naphtalényle une fois ou deux avec Cl-6alkyloxy.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)