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1. WO2005105782 - DIASTEREOSELECTIVE ADDITION OF LITHIATED N-METHYLIMIDAZOLE ON SULFINIMINES

Publication Number WO/2005/105782
Publication Date 10.11.2005
International Application No. PCT/EP2005/051928
International Filing Date 28.04.2005
IPC
C07D 401/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 215/227
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20Oxygen atoms
22attached in position 2 or 4
227only one oxygen atom which is attached in position 2
C07D 401/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Applicants
  • JANSSEN PHARMACEUTICA N.V. [BE]/[BE] (AllExceptUS)
  • FILLIERS, Walter, Ferdinand, Maria [BE]/[BE] (UsOnly)
  • BROECKX, Rudy, Laurent, Maria [BE]/[BE] (UsOnly)
  • ANGIBAUD, Patrick, René [FR]/[FR] (UsOnly)
Inventors
  • FILLIERS, Walter, Ferdinand, Maria
  • BROECKX, Rudy, Laurent, Maria
  • ANGIBAUD, Patrick, René
Common Representative
  • JANSSEN PHARMACEUTICA N.V.
Priority Data
04076320.303.05.2004EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DIASTEREOSELECTIVE ADDITION OF LITHIATED N-METHYLIMIDAZOLE ON SULFINIMINES
(FR) ADDITION DIASTEREOSELECTIVE DE N-METHYLIMIDAZOLE LITHIEE SUR DES SULFINIMINES
Abstract
(EN) A diastereoselective synthesis process for the preparation of (R)-(+)- 6-[amino(4­-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl­2(1H)-quinolinone which comprises the preparation of a compound of formula (VIII) and the stereochemically isomeric forms thereof wherein R is C1-6alkyl or C1-6alkylphenyl-.
(FR) L'invention concerne un procédé de synthèse diastéréosélective pour la préparation de (R)-(+)- 6-[amino(4-chlorophényl)(1-méthyl-1H-imidazol-5-yl)méthyl]-4-(3-chlorophényl)-1-méthyl-2(1H)-quinolinone faisant appel à la préparation d'un composé de formule (VIII) ainsi que des formes stéréochimiquement isomères de ce dernier. Dans ladite formule (VIII), R représente alkyle C1-6 ou alkylphényle C1-6.
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