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1. (WO2005105213) INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/105213    International Application No.:    PCT/EP2005/051908
Publication Date: 10.11.2005 International Filing Date: 27.04.2005
Chapter 2 Demand Filed:    12.07.2006    
IPC:
A61K 31/00 (2006.01), A61K 31/282 (2006.01), A61K 31/337 (2006.01), A61K 31/404 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01)
Applicants: NIKEM RESEARCH S.R.L. [IT/IT]; Via Zambeletti 25, I-20021 BARANZATE DI BOLLATE (IT) (For All Designated States Except US).
ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI [IT/IT]; Via Venezian, 1, I-20133 MILANO (IT) (For All Designated States Except US).
FARINA, Carlo [IT/IT]; (IT) (For US Only).
GAGLIARDI, Stefania [IT/IT]; (IT) (For US Only).
MISIANO, Paola [IT/IT]; (IT) (For US Only).
CELESTINI, Paolo [IT/IT]; (IT) (For US Only).
ZUNINO, Franco [IT/IT]; (IT) (For US Only)
Inventors: FARINA, Carlo; (IT).
GAGLIARDI, Stefania; (IT).
MISIANO, Paola; (IT).
CELESTINI, Paolo; (IT).
ZUNINO, Franco; (IT)
Agent: GERLI, Paolo; NOTARBARTOLO & GERVASI S.p.A., Corso di Porta Vittoria 9, I-20122 MILAN (IT)
Priority Data:
MI2004A000874 30.04.2004 IT
Title (EN) INDOLE AND AZAINDOLE DERIVATIVES WITH ANTITUMOR ACTION
(FR) DERIVES D'INDOLE ET D'AZAINDOLE PRESENTANT UNE ACTIVITE ANTITUMORALE
Abstract: front page image
(EN)Indole and azaindole compounds useful for the treatment of solid tumours and tumours of the blood are described, they being particularly effective in the treatment of drug resistant tumours; these compounds are also able to synergistically enhance the activity of known antitumour drugs. They can hence be used either alone as antitumour agents or in association with known antitumour drugs. Processes for preparing the aforesaid compounds, which are partly new, and pharmaceutical compositions useful for the aforesaid treatments are also described.
(FR)L'invention concerne des composés d'indole et d'azaindole utiles pour traiter des tumeurs solides et des tumeurs sanguines. Ces dérivés sont particulièrement efficaces pour traiter des tumeurs résistant aux médicaments. Ces composés permettent également d'accroître synergétiquement l'activité de médicaments antitumoraux connus. Par conséquent, ils peuvent être utilisés soit seuls, soit en tant qu'agents antitumoraux, ou associés à des médicaments antitumoraux connus. Des procédés pour préparer les composés susmentionnés, qui sont partiellement nouveaux, et des compositions pharmaceutiques utiles pour les traitements susmentionnés sont également décrits dans la description.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)