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5. WO2005105035 - TARGETED NANOPARTICLES FOR DRUG DELIVERY

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Publication Number WO/2005/105035
Publication Date 10.11.2005
International Application No. PCT/IE2005/000047
International Filing Date 29.04.2005
IPC
A61K 47/48 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61K 9/51 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
51Nanocapsules
CPC
A61K 47/6923
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6921the form being a particulate, a powder, an adsorbate, a bead or a sphere
6923the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
A61K 47/6929
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6921the form being a particulate, a powder, an adsorbate, a bead or a sphere
6927the form being a solid microparticle having no hollow or gas-filled cores
6929the form being a nanoparticle, e.g. an immuno-nanoparticle
A61K 49/0067
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
001Preparation for luminescence or biological staining
0063characterised by a special physical or galenical form, e.g. emulsions, microspheres
0065the luminescent/fluorescent agent having itself a special physical form, e.g. gold nanoparticle
0067quantum dots, fluorescent nanocrystals
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
B82Y 5/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Applicants
  • THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH [IE]/[IE](AllExceptUS)
  • GOUNKO, Iouri, Kuzmich [BY]/[IE](UsOnly)
  • RAKOVICH, Yury [BY]/[IE](UsOnly)
  • VOLKOV, Yuri [IE]/[IE](UsOnly)
  • DONGEGAN, John [IE]/[IE](UsOnly)
  • KELLEHER, Dermot [IE]/[IE](UsOnly)
  • MITCHELL, Siobhan [IE]/[IE](UsOnly)
Inventors
  • GOUNKO, Iouri, Kuzmich
  • RAKOVICH, Yury
  • VOLKOV, Yuri
  • DONGEGAN, John
  • KELLEHER, Dermot
  • MITCHELL, Siobhan
Agents
  • O'BRIEN, John, A.
Priority Data
60/566,08529.04.2004US
Publication Language English (en)
Filing Language English (en)
Designated States
Title
(EN) TARGETED NANOPARTICLES FOR DRUG DELIVERY
(FR) SYSTEME D'ADMINISTRATION
Abstract
(EN) Therapeutic drug delivery and diagnostics systems comprise biologically active compounds associated with particulate carriers of less than 20nm. These systems can be utilised for targeted modification of growth, development and functions, such as gene expression, protein synthesis, intracellular energy production and transport mechanisms in prokaryotic and eukaryotic organisms. The systems are also applicable for controlled modification of structural and functional properties of extracellular components and tissue constituents. The characteristics of a biological site are evaluated and an entity is provided which is dependent on the site characteristics. The entity comprises nanoparticles of less than 20nm. A probe comprising nanoparticles of less than 5nm is also provided.
(FR) L'invention porte sur des systèmes d'administration de médicaments thérapeutiques et de diagnostic comprenant des composés actifs associés à des supports particulaires inférieurs à 20nm. Ces systèmes peuvent servir à la modification ciblée de croissance, de développement et de fonctions, telle que l'expression génique, la synthèse de protéines, la production d'énergie intracellulaire et de mécanismes de transport dans des organismes procaryotes et eucaryotes. Ces systèmes peuvent aussi être utilisés en vue de la modification contrôlée de propriétés structurelles et fonctionnelles de composés extracellulaires et de constituants tissulaires. Les caractéristiques d'un site biologique sont évaluées et une entité est obtenue, laquelle dépend des caractéristiques du site. Cette entité comprend des nanoparticules inférieures à 20nm. L'invention porte aussi sur une sonde comprenant des nanoparticules inférieures à 5nm.
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