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5. (WO2005105035) TARGETED NANOPARTICLES FOR DRUG DELIVERY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2005/105035 International Application No.: PCT/IE2005/000047
Publication Date: 10.11.2005 International Filing Date: 29.04.2005
IPC:
A61K 47/48 (2006.01) ,A61K 9/51 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
Applicants:
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH [IE/IE]; College Green Dublin 2, IE (AllExceptUS)
GOUNKO, Iouri, Kuzmich [BY/IE]; IE (UsOnly)
RAKOVICH, Yury [BY/IE]; IE (UsOnly)
VOLKOV, Yuri [IE/IE]; IE (UsOnly)
DONGEGAN, John [IE/IE]; IE (UsOnly)
KELLEHER, Dermot [IE/IE]; IE (UsOnly)
MITCHELL, Siobhan [IE/IE]; IE (UsOnly)
Inventors:
GOUNKO, Iouri, Kuzmich; IE
RAKOVICH, Yury; IE
VOLKOV, Yuri; IE
DONGEGAN, John; IE
KELLEHER, Dermot; IE
MITCHELL, Siobhan; IE
Agent:
O'BRIEN, John, A.; c/o John A. O'Brien & Associates Third Floor, Duncairn House 14 Carysfort Avenue Blackrock County Dublin, IE
Priority Data:
60/566,08529.04.2004US
Title (EN) TARGETED NANOPARTICLES FOR DRUG DELIVERY
(FR) SYSTEME D'ADMINISTRATION
Abstract:
(EN) Therapeutic drug delivery and diagnostics systems comprise biologically active compounds associated with particulate carriers of less than 20nm. These systems can be utilised for targeted modification of growth, development and functions, such as gene expression, protein synthesis, intracellular energy production and transport mechanisms in prokaryotic and eukaryotic organisms. The systems are also applicable for controlled modification of structural and functional properties of extracellular components and tissue constituents. The characteristics of a biological site are evaluated and an entity is provided which is dependent on the site characteristics. The entity comprises nanoparticles of less than 20nm. A probe comprising nanoparticles of less than 5nm is also provided.
(FR) L'invention porte sur des systèmes d'administration de médicaments thérapeutiques et de diagnostic comprenant des composés actifs associés à des supports particulaires inférieurs à 20nm. Ces systèmes peuvent servir à la modification ciblée de croissance, de développement et de fonctions, telle que l'expression génique, la synthèse de protéines, la production d'énergie intracellulaire et de mécanismes de transport dans des organismes procaryotes et eucaryotes. Ces systèmes peuvent aussi être utilisés en vue de la modification contrôlée de propriétés structurelles et fonctionnelles de composés extracellulaires et de constituants tissulaires. Les caractéristiques d'un site biologique sont évaluées et une entité est obtenue, laquelle dépend des caractéristiques du site. Cette entité comprend des nanoparticules inférieures à 20nm. L'invention porte aussi sur une sonde comprenant des nanoparticules inférieures à 5nm.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20080063720