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1. (WO2005103684) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH CX3C CHEMOKINE RECEPTOR 1 (CX3CR1)
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/103684    International Application No.:    PCT/EP2005/004018
Publication Date: 03.11.2005 International Filing Date: 15.04.2005
IPC:
C07K 14/705 (2006.01), C12Q 1/68 (2006.01), G01N 33/48 (2006.01), G01N 33/68 (2006.01)
Applicants: BAYER HEALTHCARE AG [DE/DE]; 51368 Leverkusen (DE) (For All Designated States Except US).
GOLZ, Stefan [DE/DE]; (DE) (For US Only).
BRÜGGEMEIER, Ulf [DE/DE]; (DE) (For US Only).
GEERTS, Andreas [DE/DE]; (DE) (For US Only)
Inventors: GOLZ, Stefan; (DE).
BRÜGGEMEIER, Ulf; (DE).
GEERTS, Andreas; (DE)
Common
Representative:
BAYER HEALTHCARE AG; Law and Patents, Patents and Licensing, 51368 Leverkusen (DE)
Priority Data:
04009259.5 20.04.2004 EP
Title (EN) DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH CX3C CHEMOKINE RECEPTOR 1 (CX3CR1)
(FR) DIAGNOSTICS ET METHODES THERAPEUTIQEUS POUR DES MALADIES ASSOCIEES AU RECEPTEUR 1 DE LA CHIMIOKINE CX3C
Abstract: front page image
(EN)The invention provides a human CX3CR1 which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, cancer, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, cancer, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CX3CR1 as well as pharmaceutical compositions comprising such compounds.
(FR)L'invention concerne un récepteur CX3CR1 humain associé aux maladies cardio-vasculaires, aux maladies dermatologiques, aux maladies endocrinologiques, aux troubles du métabolisme, à l'inflammation, aux maladies gastro-intestinales, aux maladies hématologiques, aux maladies respiratoires, au cancer, aux maladies neurologiques, et aux maladies urologiques. L'invention concerne également des essais biologiques permettant d'identifier des composés utilisés dans le traitement ou la prévention des maladies cardio-vasculaires, des maladies dermatologiques, des maladies endocrinologiques, des troubles du métabolisme, de l'inflammation, des maladies gastro-intestinales, des maladies hématologiques, des maladies respiratoires, du cancer, des maladies neurologiques, et des maladies urologiques. L'invention concerne également des composés qui lient et/ou activent ou inhibent l'activité du CX3CR1 ainsi que des compositions pharmaceutiques comprenant lesdits composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)