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1. (WO2005103162) FLUORESCENT LABELED NUCLEOTIDE DERIVATIVES

Pub. No.:    WO/2005/103162    International Application No.:    PCT/US2005/009330
Publication Date: Nov 3, 2005 International Filing Date: Mar 22, 2005
IPC: C09B 23/01
C09B 23/08
C09B 23/12
C12Q 1/68
G01N 21/64
G01N 33/58
Applicants: BECKMAN COULTER, INC.
SHEN, Gene, G.-Y.
LIN, Yuan
MICHAEL, Josephine, M.
Inventors: SHEN, Gene, G.-Y.
LIN, Yuan
MICHAEL, Josephine, M.
Title: FLUORESCENT LABELED NUCLEOTIDE DERIVATIVES
Abstract:
Fluorescent labeled reporter compounds having a modified cyanine dye that is coupled to a nucleotide derivative through a linker are disclosed. The compounds are useful for nucleic acid sequence analysis. The fluorescent labeled reporter compounds are ring-locked cyanine dyes that are coupled to a nucleotide derivative, such as a modified DNA base, through a linker. These fluorescent labeled reporter compounds can be used as DNA chain-terminators in DNA synthesis to generate DNA fragments that are fluorescently-labeled at the 3'-terminal end of the DNA fragment.