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1. (WO2005103057) 6,7-DIHYDROXY-8-PHENYL-3,6,7,8-TETRAHYDRO-CHROMENO[7, 8-D]IMIDAZOLE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS

Pub. No.:    WO/2005/103057    International Application No.:    PCT/EP2005/051822
Publication Date: Nov 3, 2005 International Filing Date: Apr 22, 2005
IPC: C07D 491/04
C07D 491/14
A61K 31/4188
Applicants: ALTANA PHARMA AG
BUHR, Wilm
Inventors: BUHR, Wilm
ZIMMERMANN, Peter Jan
BREHM, Christof
PALMER, Andreas
CHIESA, M. Vittoria
SIMON, Wolfgang-Alexander
POSTIUS, Stefan
KROMER, Wolfgang
SENN-BILFINGER, Joerg
Title: 6,7-DIHYDROXY-8-PHENYL-3,6,7,8-TETRAHYDRO-CHROMENO[7, 8-D]IMIDAZOLE DERIVATIVES AND THEIR USE AS GASTRIC ACID SECRETION INHIBITORS
Abstract:
The invention provides compounds of formula (1), in which R1 is hydrogen, halogen, 1-4C-alkyl, 3-7-Ccycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4-alkoxy, 1-4C-alkoxy-1-4C-alkyl, 1-4C-alkoxycarbonyl, 2-4C-alkenyl, 2-4C-alkynyl, fluoro-1-4C-alkyl, fluoro-1-4C-alkoxy-1-4C-alkyl or hydroxy-1-4C-alkyl, R2 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, 2-4C-alkenyl, 2-4C-alkynyl, fluoro-1-4C-alkyl or hydroxy-1-4C-alkyl, R3 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, fluoro-1-4C-alkyl, fluoro-1-4C-alkoxy-1-4C-alkyl or hydroxy-1-4C-alkyl, R4 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkyl, fluoro-1-4C-alkyl, fluoro-1-4C-alkoxy-1-4C-alkyl, hydroxy-1-4C-alkyl, 1-4C-alkoxy-1-4C-alkylcarbonyl, mono- or di-1-4C-alkylamino-1-4C-alkylcarbonyl or 1-4C-alkylcarbonyl or where R3 and R4 together form a methylen (-CH2-), an ethylen (-CH2-CH2-), a propylen (-CH2-CH2-CH2-) or an isopropylidene (-C(-CH3)2-) radical, R5 is hydrogen, halogen, 1-4C-alkyl or fluoro-1-4C-alkyl, R6 is hydrogen, halogen, 1-4C- alkyl or fluoro-1-4C-alkyl, and the salts of these compounds. The compounds inhibit the secretion of gastric acid.