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Machine translation
1. (WO2005103031) NOVEL ALKYNE COMPOUNDS WITH AN MCH-ANTAGONISTIC ACTION AND MEDICAMENTS CONTAINING SAID COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/103031    International Application No.:    PCT/EP2005/003683
Publication Date: 03.11.2005 International Filing Date: 08.04.2005
IPC:
C07D 213/30 (2006.01), C07D 213/61 (2006.01), C07D 401/12 (2006.01), C07D 405/12 (2006.01), C07D 409/14 (2006.01)
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH [DE/DE]; Binger Strasse 173, 55216 Ingelheim (DE) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG [DE/DE]; Binger Strasse 173, 55216 Ingelheim (DE) (DE only).
STENKAMP, Dirk [DE/DE]; (DE) (For US Only).
MUELLER, Stephan Georg [DE/DE]; (DE) (For US Only).
LUSTENBERGER, Philipp [CH/CH]; (CH) (For US Only).
LEHMANN-LINTZ, Thorsten [DE/DE]; (DE) (For US Only).
THOMAS, Leo [DE/DE]; (DE) (For US Only).
SCHINDLER, Marcus [DE/DE]; (DE) (For US Only).
ROTH, Gerald Jürgen [DE/DE]; (DE) (For US Only).
RUDOLF, Klaus [DE/DE]; (DE) (For US Only).
LOTZ, Ralf R. H. [DE/DE]; (DE) (For US Only)
Inventors: STENKAMP, Dirk; (DE).
MUELLER, Stephan Georg; (DE).
LUSTENBERGER, Philipp; (CH).
LEHMANN-LINTZ, Thorsten; (DE).
THOMAS, Leo; (DE).
SCHINDLER, Marcus; (DE).
ROTH, Gerald Jürgen; (DE).
RUDOLF, Klaus; (DE).
LOTZ, Ralf R. H.; (DE)
Common
Representative:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; Binger Strasse 173, 55216 Ingelheim (DE)
Priority Data:
10 2004 017 935.2 14.04.2004 DE
Title (DE) NEUE ALKIN-VERBINDUNGEN MIT MCH-ANTAGONISTISCHER WIRKUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL
(EN) NOVEL ALKYNE COMPOUNDS WITH AN MCH-ANTAGONISTIC ACTION AND MEDICAMENTS CONTAINING SAID COMPOUNDS
(FR) NOUVEAUX COMPOSES D'ALCYNE A EFFET ANTAGONISTE VIS-A-VIS DE MCH ET MEDICAMENTS CONTENANT CES COMPOSES
Abstract: front page image
(DE)Die vorliegende Erfindung betrifft Alkin-Verbindungen der allgemeinen Formel I in der die Gruppen und Reste A, B, W, X, Y, Z, R1 und R2 die in Anspruch 1 angegebenen Bedeutungen aufweisen. Ferner betrifft die Erfindung Arzneimittel enthaltend mindestens ein erfindungsgemäßes Alkin. Auf Grund der MCH-Rezeptor antagonistischen Aktivität eignen sich die erfindungsgemäßen Arzneimittel zur Behandlung von metabolischen Störungen und/oder Essstörungen, insbesondere von Adipositas und Diabetes.
(EN)The invention relates to alkyne compounds of general formula (I), in which the groups and radicals A, B, W, X, Y, Z, R1 and R2 are defined as cited in claim 1. The invention also relates to medicaments containing at least one inventive alkyne. As a result of the antagonistic action against the MCH-receptor, the inventive medicaments are suitable for treating metabolic disorders and/or eating disorders, in particular adiposity and diabetes.
(FR)L'invention concerne des composés d'alcyne de formule générale (I), dans laquelle les groupes et les radicaux A, B, W, X, Y, Z, R1 et R2 ont la signification indiquée dans la revendication 1. L'invention concerne en outre des médicaments contenant au moins une alcyne selon l'invention. En raison de l'effet antagoniste de ces composés vis-à-vis du récepteur MCH, les médicaments selon l'invention sont appropriés pour le traitement de troubles métaboliques et/ou de troubles nutritionnels, notamment de l'adiposité et du diabète.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)