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1. (WO2005103030) 1,4-DI SUBSTITUTED BENZENE COMPOUNDS, PROCESS FOR PREPARING THE SAME AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/103030    International Application No.:    PCT/CN2005/000029
Publication Date: 03.11.2005 International Filing Date: 10.01.2005
IPC:
A61K 31/435 (2006.01), A61K 31/47 (2006.01), A61K 31/4725 (2006.01), A61K 31/495 (2006.01), A61P 37/06 (2006.01), C07C 63/66 (2006.01), C07C 211/44 (2006.01), C07C 211/45 (2006.01), C07C 211/54 (2006.01), C07C 307/02 (2006.01), C07C 309/32 (2006.01), C07C 321/28 (2006.01), C07C 321/30 (2006.01), C07D 213/04 (2006.01), C07D 213/24 (2006.01), C07D 213/60 (2006.01), C07D 213/78 (2006.01), C07D 215/04 (2006.01), C07D 215/12 (2006.01), C07D 215/16 (2006.01), C07D 215/48 (2006.01), C07D 241/36 (2006.01), C07D 401/10 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 405/10 (2006.01), C07D 413/00 (2006.01), C07D 413/12 (2006.01), C07D 413/14 (2006.01)
Applicants: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; 555 Zu Chong Zhi Road, Pudong New District, Shanghai 201203 (CN) (For All Designated States Except US).
JIANG, Hualiang [CN/CN]; (CN) (For US Only).
SHEN, Xu [CN/CN]; (CN) (For US Only).
SHEN, Jianhua [CN/CN]; (CN) (For US Only).
LIU, Hong [CN/CN]; (CN) (For US Only).
LUO, Xiaomin [CN/CN]; (CN) (For US Only).
GUI, Chunshan [CN/CN]; (CN) (For US Only).
LI, Jian [CN/CN]; (CN) (For US Only).
GUO, Hongxia [CN/CN]; (CN) (For US Only).
LI, Chenjing [CN/CN]; (CN) (For US Only).
CHEN, Kaixian [CN/CN]; (CN) (For US Only)
Inventors: JIANG, Hualiang; (CN).
SHEN, Xu; (CN).
SHEN, Jianhua; (CN).
LIU, Hong; (CN).
LUO, Xiaomin; (CN).
GUI, Chunshan; (CN).
LI, Jian; (CN).
GUO, Hongxia; (CN).
LI, Chenjing; (CN).
CHEN, Kaixian; (CN)
Agent: SHANGHAI KAIJI INTELLECTUAL PROPERTY AGENT CO., LTD.; Rm. 1501, 188 Nandandong Road, Shanghai 200030 (CN)
Priority Data:
200410016618.3 27.02.2004 CN
Title (EN) 1,4-DI SUBSTITUTED BENZENE COMPOUNDS, PROCESS FOR PREPARING THE SAME AND USE THEREOF
(FR) COMPOSES DE BENZENE A DI-SUBSTITUTION EN POSITIONS 1,4, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION
Abstract: front page image
(EN)The present invention provides small-molecule 1,4-di substituted benzene compounds as non-peptide ligands of cyclophilin A, which have the structure as general formula I. By biological activity tests, it has been indicated that the compounds according to the present invention have relatively strong combining capacity with cyclophilin A, thereby it is proved that the mechanism of action is to induce immunodepression. The present invention also provides the process of preparing the said compounds.
(FR)La présente invention concerne des composés de benzène à di-substitution en positions 1,4 à petites molécules utilisés comme ligands non peptidiques de cyclophiline A, lesquels ont la structure selon la formule générale (I). Des tests d'activité biologique ont permis d'indiquer que les composés de la présente invention présentent une capacité de combinaison relativement forte avec la cyclophiline A, il est ainsi prouvé que le mécanisme d'action permet d'induire une immunodépression. La présente invention concerne également le procédé de préparation desdits composés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)