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1. (WO2005103020) 1,3,5-SUBSTITUTED PHENYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

Pub. No.:    WO/2005/103020    International Application No.:    PCT/US2005/012973
Publication Date: Nov 3, 2005 International Filing Date: Apr 15, 2005
IPC: C07D 271/10
Applicants: MERCK & CO., INC.
BARROW, James, C.
MCGAUGHEY, Georgia, B.
NANTERMET, Philippe, G.
RAJAPAKSE, Hemaka, A.
SELNICK, Harold, G.
STAUFFER, Shaun, R.
COBURN, Craig, A.
Inventors: BARROW, James, C.
MCGAUGHEY, Georgia, B.
NANTERMET, Philippe, G.
RAJAPAKSE, Hemaka, A.
SELNICK, Harold, G.
STAUFFER, Shaun, R.
COBURN, Craig, A.
Title: 1,3,5-SUBSTITUTED PHENYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
Abstract:
The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.