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Machine translation
1. (WO2005102316) USE OF COUMARIN DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2005/102316    International Application No.:    PCT/EP2005/004250
Publication Date: 03.11.2005 International Filing Date: 20.04.2005
Chapter 2 Demand Filed:    27.01.2006    
IPC:
A61K 31/37 (2006.01), A61K 31/7048 (2006.01), A61P 25/00 (2006.01), A61P 25/28 (2006.01), A61P 21/04 (2006.01), A61P 25/16 (2006.01)
Applicants: INTE:LIGAND [AT/AT]; Software Entwicklungs und Consulting GmbH, Clemens Maria Hofbauer-G. 6, A-2344 Maria Enzersdorf (AT) (For All Designated States Except US).
LEOPOLD-FRANZENS UNIVERSITÄT INNSBRUCK [AT/AT]; Christoph-Probst-Platz, Innrain 52, A-6020 Innsbruck (AT) (For All Designated States Except US).
STUPPNER, Hermann [IT/AT]; (AT) (For US Only).
LANGER, Thierry [AT/AT]; (AT) (For US Only).
PRAST, Helmut [AT/AT]; (AT) (For US Only).
ROLLINGER, Judith [AT/AT]; (AT) (For US Only).
WOLBER, Gerhard [AT/AT]; (AT) (For US Only)
Inventors: STUPPNER, Hermann; (AT).
LANGER, Thierry; (AT).
PRAST, Helmut; (AT).
ROLLINGER, Judith; (AT).
WOLBER, Gerhard; (AT)
Agent: GOLDBACH, Klara; Grünecker, Kinkeldey, Stockmair & Schwanhäusser, Maximilianstrasse 58, 80538 München (DE)
Priority Data:
04009431.0 21.04.2004 EP
Title (EN) USE OF COUMARIN DERIVATIVES
(FR) UTILISATION DE DERIVES DE COUMARINE
Abstract: front page image
(EN)The present invention relates to the use of a coumarin derivative having a coumarin skeleton of Formula (I) wherein the coumarin skeleton is substituted by one OR1 and one OR2 whereby R1 is C1 to C6 alkyl, C3 to C7 cycloalkyl or C2 to C6 alkenyl and R2 is hydrogen or a sugar moiety, preferably scopoletin or scopolin for the preparation of a medicament for the prophylaxis or treatment of disorders which involve low levels of acetylcholine in the brain. The coumarin derivatives of Formula (I) inhibit acetylcholinesterase in vitro and enhance acetylcholine concentration in the brain in vivo, and therefore, can ameliorate disorders connected with deficits in learning and memory functions like Alzheimer’s disease, senile dementia, ataxia, myasthenia gravis and Parkinson’s disease.
(FR)L'invention concerne l'utilisation d'un dérivé de coumarine possédant un squelette de formule (I) dans laquelle le squelette est substitué par un OR1 et un OR2, R1 désignant C1 à C6 alkyle, C3 à C7 cycloalkyle ou C2 à C6 alcényle et R2 représentant l'hydrogène ou une fraction de sucre, pour la préparation d'un médicament destiné à la prophylaxie ou au traitement de troubles impliquant des niveaux bas d'acétylcholine dans le cerveau. Les dérivés de coumarine de formule (I) inhibent l'acétylcholinestérase <i>in vitro </i>et améliorent la concentration en acétylcholine dans le cerveau <i>in vivo, </i> et peuvent, par conséquent, améliorer des troubles liés à des déficits des fonctions de l'apprentissage et de la mémoire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)