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1. WO2005100333 - METHODS AND INTERMEDIATES FOR THE SYNTHESIS OF DELTA-9 TETRAHYDROCANNABINOL

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Publication Number WO/2005/100333
Publication Date 27.10.2005
International Application No. PCT/US2005/011974
International Filing Date 07.04.2005
IPC
C07D 239/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
C07D 265/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
265Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
041,3-Oxazines; Hydrogenated 1,3-oxazines
12condensed with carbocyclic rings or ring systems
C07D 279/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
279Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
101,4-Thiazines; Hydrogenated 1,4-thiazines
14condensed with carbocyclic rings or ring systems
16condensed with one six-membered ring
C07D 311/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
04Benzo pyrans, not hydrogenated in the carbocyclic ring
C07D 311/94 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
94condensed with rings other than six-membered or with ring systems containing such rings
C07D 321/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
321Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/-C07D319/174
CPC
C07B 2200/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
07Optical isomers
C07C 2601/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
12with a six-membered ring
16the ring being unsaturated
C07C 29/106
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
29Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
09by hydrolysis
10of ethers, including cyclic ethers, e.g. oxiranes
103of cyclic ethers
106of oxiranes
C07D 303/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
303Compounds containing three-membered rings having one oxygen atom as the only ring heteroatom
02Compounds containing oxirane rings
04containing only hydrogen and carbon atoms in addition to the ring oxygen atoms
C07D 303/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
303Compounds containing three-membered rings having one oxygen atom as the only ring heteroatom
02Compounds containing oxirane rings
12with hydrocarbon radicals substituted by singly or doubly bound oxygen atoms
14by free hydroxyl radicals
C07D 311/80
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
80Dibenzopyrans; Hydrogenated dibenzopyrans
Applicants
  • CEDARBURG PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • CABAJ, John, E. [US]/[US] (UsOnly)
  • PARIZA, Richard, J. [US]/[US] (UsOnly)
  • LUKESH, Julie [US]/[US] (UsOnly)
Inventors
  • CABAJ, John, E.
  • PARIZA, Richard, J.
  • LUKESH, Julie
Agents
  • ROCHE, Richard, T.
Priority Data
60/560,32707.04.2004US
60/607,08003.09.2004US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND INTERMEDIATES FOR THE SYNTHESIS OF DELTA-9 TETRAHYDROCANNABINOL
(FR) METHODES ET INTERMEDAIRES POUR LA SYNTHESE DE TETRAHYDROCANNABINOL DELTA-9
front page image
Abstract
(EN)
Processes are disclosed for the synthesis of Delta-9 tetrahydrocannabinol which result in an improved Y-THC/Y-THC ratio, and intermediates are disclosed that may be used in the synthesis of Delta-9 tetrahydrocannabinol such that improved Y-THCIY-THC ratios are achieved. The intermediates may be cyclic compounds prepared from 2-Carene. There is also provided a scaleable process for the preparation of (+)-p-menth-2-ene-1, 8-diol,, another intermediate used in the synthesis of delta-9-tetrahydrocannibinol.
(FR)
L'invention concerne des procédés pour la synthèse de tétrahydrocannabinol delta-9 permettant d'obtenir un rapport $g(D)9-THC/$g(D)8-THC amélioré, et des intermédiaires pouvant être utilisés dans la synthèse de tétrahydrocannabinol delta-9, de sorte à atteindre des rapports $g(D)9-THC/$g(D)8-THC améliorés. Ces intermédiaires peuvent être des composés cycliques préparés à partir de carène 2. L'invention concerne également un procédé pouvant être mis à l'échelle pour la préparation de (+)-p-menth-2-ène-1, 8-diol, un autre intermédiaire utilisé pour la synthèse de tétrahydrocannabinol delta-9.
Also published as
EP1732908
US20070287843
Latest bibliographic data on file with the International Bureau
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