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1. WO2005100321 - PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES

Publication Number WO/2005/100321
Publication Date 27.10.2005
International Application No. PCT/US2005/011643
International Filing Date 07.04.2005
IPC
C07D 215/44 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
42attached in position 4
44with aryl radicals attached to said nitrogen atoms
C07D 401/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
18for pancreatic disorders, e.g. pancreatic enzymes
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 11/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
08Bronchodilators
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
Applicants
  • MILLENNIUM PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • GHOSH, Shomir [IN]/[US] (UsOnly)
  • ELDER, Amy, M. [US]/[US] (UsOnly)
  • CARSON, Kenneth, G. [US]/[US] (UsOnly)
  • SPROTT, Kevin, T. [US]/[US] (UsOnly)
  • HARRISON, Sean, J. [US]/[US] (UsOnly)
  • HICKS, Frederick, A. [US]/[US] (UsOnly)
  • RENOU, Christelle, C. [FR]/[US] (UsOnly)
  • REYNOLDS, Dominic [GB]/[US] (UsOnly)
Inventors
  • GHOSH, Shomir
  • ELDER, Amy, M.
  • CARSON, Kenneth, G.
  • SPROTT, Kevin, T.
  • HARRISON, Sean, J.
  • HICKS, Frederick, A.
  • RENOU, Christelle, C.
  • REYNOLDS, Dominic
Agents
  • SHAIR, Karoline, K., M.
Priority Data
60/560,41007.04.2004US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PGD2 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES
(FR) ANTAGONISTES DE RECEPTEUR DE LA PROSTAGLANDINE D2 POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES
Abstract
(EN)
Disclosed herein are compounds represented by Structural Formula: (I) and (I-A). Also disclosed is the use of such compounds for inhibiting the G-protein coupled receptor referred to as chemoattractant receptor-homologous molecule expressed on Th2, or simply 'CRTH2' for the treatment of inflammatory disorders. The variables in Structural Formula (I) and (I-A) are defined herein.
(FR)
La présente invention a trait à des composés de formule structurelle (I) et (I-A). L'invention a également trait à l'utilisation de tels composés pour l'inhibition de récepteur couplé à une protéine G désigné molécule homologue de récepteur à fonction chimioattractive exprimée sur le Th2, ou simplement CRTH2' pour le traitement de troubles inflammatoires. Les variables de la formule structurelle (I) et (I-A) sont tels que définis dans la description.
Also published as
NI2006-000222 I
CRCR2006-008659
NI2006-000222 I
NZ550355
PH12006501984
DZDZP2006000515
ZA200608955
CO6112392
RU2006138603
NO20065107
Latest bibliographic data on file with the International Bureau