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1. WO2005095400 - AZAINDOLES USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES

Publication Number WO/2005/095400
Publication Date 13.10.2005
International Application No. PCT/US2005/010846
International Filing Date 30.03.2005
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
CPC
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/444
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
444containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A61K 31/506
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61K 31/5377
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
5377not condensed and containing further heterocyclic rings, e.g. timolol
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
Applicants
  • VERTEX PHARMACEUTICALS INCORPORATED [US]/[US] (AllExceptUS)
  • SALITURO, Francesco [US]/[US] (UsOnly)
  • FARMER, Luc [US]/[US] (UsOnly)
  • BETHIEL, Randy [US]/[US] (UsOnly)
  • HARRINGTON, Edmund [US]/[US] (UsOnly)
  • GREEN, Jeremy [GB]/[US] (UsOnly)
  • COURT, John [US]/[US] (UsOnly)
  • COME, Jon [US]/[US] (UsOnly)
  • LAUFFER, David [US]/[US] (UsOnly)
  • ARONOV, Alex [RU]/[US] (UsOnly)
  • BINCH, Hayley [GB]/[GB] (UsOnly)
  • BOYALL, Dean [GB]/[GB] (UsOnly)
  • CHARRIER, Jean-Damien [FR]/[GB] (UsOnly)
  • EVERITT, Simon [GB]/[GB] (UsOnly)
  • FRAYSSE, Damien [FR]/[GB] (UsOnly)
  • MORTIMORE, Michael [GB]/[GB] (UsOnly)
  • PIERARD, Francoise [BE]/[GB] (UsOnly)
  • ROBINSON, Daniel [GB]/[GB] (UsOnly)
  • WANG, Jian [US]/[US] (UsOnly)
  • PINDER, Joanne [GB]/[GB] (UsOnly)
  • WANG, Tiansheng [US]/[US] (UsOnly)
  • PIERCE, Albert [US]/[US] (UsOnly)
Inventors
  • SALITURO, Francesco
  • FARMER, Luc
  • BETHIEL, Randy
  • HARRINGTON, Edmund
  • GREEN, Jeremy
  • COURT, John
  • COME, Jon
  • LAUFFER, David
  • ARONOV, Alex
  • BINCH, Hayley
  • BOYALL, Dean
  • CHARRIER, Jean-Damien
  • EVERITT, Simon
  • FRAYSSE, Damien
  • MORTIMORE, Michael
  • PIERARD, Francoise
  • ROBINSON, Daniel
  • WANG, Jian
  • PINDER, Joanne
  • WANG, Tiansheng
  • PIERCE, Albert
Agents
  • BROWN, Karen, E.
Priority Data
60/557,50330.03.2004US
60/625,59905.11.2004US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) AZAINDOLES USEFUL AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES
(FR) AZAINDOLES UTILES COMME INHIBITEURS DE JANUS KINASES ET D'AUTRES PROTEINES KINASES
Abstract
(EN) The present invention relates to compounds of formula (I), which are inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
(FR) L'invention concerne des composés de formule (I) qui sont des inhibiteurs des protéines kinases. L'invention concerne également des compositions pharmaceutiques renfermant les composés selon l'invention et des procédés d'utilisation des compositions dans le traitement de divers troubles.
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