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1. WO2005094895 - PRODUCTION AND USE OF THE METHOTREXATE-ALBUMIN CONJUGATE AS AN IMMUNOSUPPRESSIVE AGENT IN GVHD

Publication Number WO/2005/094895
Publication Date 13.10.2005
International Application No. PCT/EP2005/003460
International Filing Date 01.04.2005
Chapter 2 Demand Filed 28.10.2005
IPC
A61K 31/505 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A61K 47/48 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
CPC
A61K 31/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A61K 47/643
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
643Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
Applicants
  • SINN, Hannsjörg [DE]/[DE]
Inventors
  • SINN, Hannsjörg
Agents
  • WEICKMANN & WEICKMANN
Priority Data
10 2004 016 355.302.04.2004DE
Publication Language German (de)
Filing Language German (DE)
Designated States
Title
(DE) HERSTELLUNG UND VERWENDUNG DES KONJUGATS METHOTREXAT-ALBUMIN ALS MITTEL ZUR IMMUNSUPPRESSION BEI GVHD
(EN) PRODUCTION AND USE OF THE METHOTREXATE-ALBUMIN CONJUGATE AS AN IMMUNOSUPPRESSIVE AGENT IN GVHD
(FR) FABRICATION ET UTILISATION DU CONJUGUE METHOTREXATE-ALBUMINE SERVANT D'AGENT IMMUNOSUPPRESSEUR DANS LA REACTION GREFFE CONTRE HOTE
Abstract
(DE) Die vorliegende Erfindung betrifft die Verwendung von Wirkstoff-Protein-Konjugaten zur Modulierung und insbesondere zur Vermeidung von Transplantation-assoziierten Immunreaktion. Weiterhin betrifft die Erfindung neue, vorteilhafte Herstellungsverfahren für die erfindungsgemäss einsetzbaren Konjugate.
(EN) The invention relates to the use of active ingredient protein conjugates for modulating and in particular preventing immune reactions associated with transplant operations. The invention also relates to novel advantageous production methods for the inventive conjugates.
(FR) L'invention concerne l'utilisation de conjugués agents actifs/protéines dans la modulation et notamment la prévention de réactions immunitaires associées à des transplantations. L'invention concerne également des procédés de fabrication avantageux des conjugués selon l'invention.
Related patent documents
US2007231338This application is not viewable in PATENTSCOPE because the national phase entry has not been published yet or the national entry is issued from a country that does not share data with WIPO or there is a formatting issue or an unavailability of the application.
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