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1. (WO2005094895) PRODUCTION AND USE OF THE METHOTREXATE-ALBUMIN CONJUGATE AS AN IMMUNOSUPPRESSIVE AGENT IN GVHD
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2005/094895 International Application No.: PCT/EP2005/003460
Publication Date: 13.10.2005 International Filing Date: 01.04.2005
Chapter 2 Demand Filed: 28.10.2005
IPC:
A61K 31/505 (2006.01) ,A61K 47/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
SINN, Hannsjörg [DE/DE]; DE
Inventors:
SINN, Hannsjörg; DE
Agent:
WEICKMANN & WEICKMANN ; Postfach 860 820 81635 München, DE
Priority Data:
10 2004 016 355.302.04.2004DE
Title (EN) PRODUCTION AND USE OF THE METHOTREXATE-ALBUMIN CONJUGATE AS AN IMMUNOSUPPRESSIVE AGENT IN GVHD
(FR) FABRICATION ET UTILISATION DU CONJUGUE METHOTREXATE-ALBUMINE SERVANT D'AGENT IMMUNOSUPPRESSEUR DANS LA REACTION GREFFE CONTRE HOTE
(DE) HERSTELLUNG UND VERWENDUNG DES KONJUGATS METHOTREXAT-ALBUMIN ALS MITTEL ZUR IMMUNSUPPRESSION BEI GVHD
Abstract:
(EN) The invention relates to the use of active ingredient protein conjugates for modulating and in particular preventing immune reactions associated with transplant operations. The invention also relates to novel advantageous production methods for the inventive conjugates.
(FR) L'invention concerne l'utilisation de conjugués agents actifs/protéines dans la modulation et notamment la prévention de réactions immunitaires associées à des transplantations. L'invention concerne également des procédés de fabrication avantageux des conjugués selon l'invention.
(DE) Die vorliegende Erfindung betrifft die Verwendung von Wirkstoff-Protein-Konjugaten zur Modulierung und insbesondere zur Vermeidung von Transplantation-assoziierten Immunreaktion. Weiterhin betrifft die Erfindung neue, vorteilhafte Herstellungsverfahren für die erfindungsgemäss einsetzbaren Konjugate.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)