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1. WO2005094889 - REMEDY OR PREVENTIVE FOR ARTHRITIS

Publication Number WO/2005/094889
Publication Date 13.10.2005
International Application No. PCT/JP2005/006831
International Filing Date 31.03.2005
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 45/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 17/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
CPC
A61K 38/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 38/2242
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
22Hormones
2242Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
Applicants
  • 中外製薬株式会社 CHUGAI SEIYAKU KABUSHIKI KAISHA [JP]/[JP] (AllExceptUS)
  • 中尾 一和 NAKAO, Kazuwa [JP]/[JP]
  • 北村 秀智 KITAMURA, Hidetomo [JP]/[JP] (UsOnly)
Inventors
  • 中尾 一和 NAKAO, Kazuwa
  • 北村 秀智 KITAMURA, Hidetomo
Agents
  • 平木 祐輔 HIRAKI, Yusuke
Priority Data
2004-10792431.03.2004JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) REMEDY OR PREVENTIVE FOR ARTHRITIS
(FR) REMÈDE OU MÉDICAMENT PRÉVENTIF POUR L'ARTHRITE
(JA) 関節炎症治療剤又は予防剤
Abstract
(EN)
It is intended to provide a novel remedy or a preventive for arthritis such as arthritis deformans. More specifically speaking, a remedy or a preventive for arthritis such as arthritis deformans or a joint cartilage cell growth promoter characterized by containing, as the active ingredient, a guanyl cyclase B (GC-B) activator; a method of inhibiting arthritis or a method of promoting the growth of joint cartilage cells by activating GC-B; or a method of screening a joint cartilage cell growth promoter or a remedy for arthritis by using GC-B activity as an indication.
(FR)
Il est prévu de fournir un remède novateur ou un médicament préventif pour l'arthrite telle que l'arthritis deformans (polyarthrite rhumatoïde). Plus particulièrement, un remède ou un médicament préventif destiné à l'arthrite telle que l'arthritis deformans ou un promoteur de croissance de cellules de cartilage articulaire, caractérisé en ce qu'il contient un activateur de guanyl cyclase B (GC-B), un procédé d'inhibition de l'arthrite ou un procédé favorisant la croissance de cellules de cartilage articulaire en activant la GC-B ou un procédé de dépistage d'un promoteur de croissance des cellules de cartilage articulaire ou un remède pour l'arthrite en utilisant l'activité de la GC-B comme indication.
(JA)
 本発明は、変形性関節症などの関節炎症に対する新しい治療剤または予防剤を提供する。具体的には、本発明は、グアニルシクラーゼB(GC-B)活性化物質を有効成分として含むことを特徴とする、変形性関節炎症などの関節炎症の治療剤、予防剤または関節軟骨細胞増殖促進剤、あるいは、GC-Bを活性化することによる関節炎症の抑制方法又は関節軟骨細胞の増殖促進方法、あるいは、GC-Bの活性を指標とした関節軟骨細胞増殖促進剤又は関節炎症治療剤のスクリーニング方法を提供する。
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