Processing

Please wait...

Settings

Settings

Goto Application

1. WO2005094823 - Flt-3 INHIBITOR

Publication Number WO/2005/094823
Publication Date 13.10.2005
International Application No. PCT/JP2005/006032
International Filing Date 30.03.2005
IPC
A61K 31/4439 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/496 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A61P 7/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
A61P 19/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
CPC
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 7/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
C07D 231/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54condensed with carbocyclic rings or ring-systems
56Benzopyrazoles; Hydrogenated benzopyrazoles
Applicants
  • 協和▲醗▼酵工業株式会社 KYOWA HAKKO KOGYO CO., LTD. [JP]/[JP] (AllExceptUS)
  • 塩津 行正 SHIOTSU, Yukimasa [JP]/[JP] (UsOnly)
  • 梅原 浩司 UMEHARA, Hiroshi [JP]/[JP] (UsOnly)
  • 山下 順範 YAMASHITA, Yoshinori [JP]/[JP] (UsOnly)
  • 鈴木 昌代 SUZUKI, Masayo [JP]/[JP] (UsOnly)
  • 金子 聡 KANEKO, Satoshi [JP]/[JP] (UsOnly)
  • 神田 裕 KANDA, Yutaka [JP]/[JP] (UsOnly)
  • 直江 知樹 NAOE, Tomoki [JP]/[JP] (UsOnly)
  • 清井 仁 KIYOI, Hitoshi [JP]/[JP] (UsOnly)
Inventors
  • 塩津 行正 SHIOTSU, Yukimasa
  • 梅原 浩司 UMEHARA, Hiroshi
  • 山下 順範 YAMASHITA, Yoshinori
  • 鈴木 昌代 SUZUKI, Masayo
  • 金子 聡 KANEKO, Satoshi
  • 神田 裕 KANDA, Yutaka
  • 直江 知樹 NAOE, Tomoki
  • 清井 仁 KIYOI, Hitoshi
Priority Data
2004-09743330.03.2004JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) Flt-3 INHIBITOR
(FR) INHIBITEUR DE Flt-3
(JA) Flt-3阻害剤
Abstract
(EN)
A Fms-like tyrosinkinase 3 (Flt-3) inhibitor which contains as an active ingredient either an indazole derivative represented by the formula (I) [wherein X represents a single bond, (CH2)n2CH=CH(CH2)n3 (wherein n2 and n3 are the same or different and each is an integer of 0 to 4), etc.; R1 represents (un)substituted aryl or an (un)substituted heterocyclic group; and R2A, R2B, R2C, and R2D are the same or different and each represents hydrogen, halogeno, (un)substituted lower alkyl, etc.; provided that not all of R2A, R2B, R2C, and R2D are hydrogen] or a pharmacologically acceptable salt thereof. (I)
(FR)
Un inhibiteur de tyrosinkinase 3 de type Fms (Flt-3) qui contient en tant qu'ingrédient actif l'un ou l'autre d'un dérivé d'indazole représenté par la formule (I) [dans laquelle X représente une liaison simple, (CH2)n2CH=CH(CH2)n3 (dans laquelle n2 et n3 sont identiques ou différents et où chacun est un nombre entier de 0 à 4), etc., R1 représente un aryle (non) substitué ou un groupement hétérocyclique (non) substitué et R2A, R2B, R2C et R2D sont identiques ou différents et où chacun représente de l'hydrogène, un groupement halogéno, un alkyle inférieur (non) substitué, etc., à condition que tous les composés R2A, R2B, R2C et R2D ne soient pas de l'hydrogène] ou un sel de celui-ci pouvant être accepté en termes pharmacologiques. (I)
(JA)
 式(I)[式中、Xは単結合、 (CH2)n2CH=CH(CH2)n3(式中、n2及びn3は、同一または異なって0から4の整数を表す)等を表し、 R1は置換もしくは非置換のアリールまたは置換もしくは非置換の複素環基を表し、 R2A、R2B、R2C及びR2Dは同一または異なって、水素原子、ハロゲン、置換もしくは非置換の低級アルキル等を表すが、R2A、R2B、R2C及びR2Dが同時に水素原子になることはない]で表されるインダゾール誘導体またはその薬理学的に許容される塩を有効成分として含有するフムス様チロシンキナーゼ3(Flt-3)阻害剤等を提供する。
Also published as
Latest bibliographic data on file with the International Bureau