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1. (WO2005092925) IMMUNOGLOBULIN VARIANTS OUTSIDE THE FC REGION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2005/092925 International Application No.: PCT/US2005/010199
Publication Date: 06.10.2005 International Filing Date: 24.03.2005
IPC:
C07K 16/00 (2006.01) ,C07K 16/28 (2006.01) ,C07K 16/30 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
Applicants:
XENCOR, INC. [US/US]; 111 West Lemon Avenue Monrovia, CA 91016, US (AllExceptUS)
LAZAR, Gregory, Alan [US/US]; US (UsOnly)
KARKI, Sher, Bahadur [NP/US]; US (UsOnly)
Inventors:
LAZAR, Gregory, Alan; US
KARKI, Sher, Bahadur; US
Agent:
SILVA, Robin, M.; Dorsey & Whitney LLP Suite 100 555 California Street San Francisco, CA 94104, US
Priority Data:
60/556,35324.03.2004US
60/573,30221.05.2004US
60/585,32801.07.2004US
60/586,83709.07.2004US
60/599,74106.08.2004US
60/607,39802.09.2004US
60/614,94429.09.2004US
60/619,40914.10.2004US
Title (EN) IMMUNOGLOBULIN VARIANTS OUTSIDE THE FC REGION
(FR) VARIANTES D'IMMUNOGLOBULINE A L'EXTERIEUR DE LA REGION FC
Abstract:
(EN) The present invention relates to antibody variants outside the Fc region that alter binding affinity to one or more effector ligands, methods for their generation, and their therapeutic application.
(FR) La présente invention concerne des variantes d'immunoglobuline à l'extérieur de la région Fc qui modifient l'affinité de liaison à un ou plusieurs ligands effecteurs, des procédés de leur génération et de leur application thérapeutique.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2053062EP1737890CA2561264AU2005227326